The DNA-damage response in human biology and disease
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Summary
The authors' improving understanding of DNA-damage responses is providing new avenues for disease management, and these responses are biologically significant because they prevent diverse human diseases.
- Type
- review
- Published
- 2009-10-22
- Cited by
- 5,860
- References
- 117
- OpenAlex
- https://openalex.org/W2145200068
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4405219
Keywords
DNA damage, DNA repair, DNA, Biology, Disease
References
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- Emerging links between the biological clock and the DNA damage response
- A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
- Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth.
Cited by
- The repair and signaling responses to DNA double-strand breaks.
- Functions of SUMO in the Maintenance of Genome Stability.
- APOPTOSIS INDUCED BY PERSISTENT SINGLE-STRAND BREAKS IN THE MITOCHONDRIAL GENOME: CRITICAL ROLE OF EXOG (5’ EXO/ENDONUCLEASE) IN THEIR REPAIR
- R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
- Hereditary breast cancer: beyond BRCA genetic analysis; PALB2 emerges
- Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
- DNA damage by reactive species: Mechanisms, mutation and repair
- The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability
- Impairment of BRCA1-related DNA Double Strand Break Repair Leads to Ovarian Aging in Mice and Humans
- Ultrahigh-throughput approach for analyzing single-cell genomic damage with an agarose-based microfluidic comet array.
- The DNA damage checkpoint response to replication stress: A Game of Forks
- Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase
- Regulation of Rad17 Protein Turnover Unveils an Impact of Rad17-APC Cascade in Breast Carcinogenesis and Treatment*
- The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.
- DNA double-strand–break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice
- Multicolor laser scanning confocal immunofluorescence microscopy of DNA damage response biomarkers.
- Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells
- Genetic Variation of Human Papillomavirus Type 16 in Individual Clinical Specimens Revealed by Deep Sequencing
- Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner
- Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling
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