The DNA damage checkpoint response to replication stress: A Game of Forks

Keywords

G2-M DNA damage checkpoint, DNA re-replication, Genome instability, DNA replication, Cell cycle checkpoint

References

• DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.Fahad Al‐Khodairy, Antony M. Carr — 1992
• Checkpoint controls in Schizosaccharomyces pombe: rad1.R. Rowley, Suresh Subramani, Paul G. Young — 1992
• Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1Katsunori Tanaka, Paul S. Russell — 2001
• Mrc1 transduces signals of DNA replication stress to activate Rad53Annette A. Alcasabas, Alexander J. Osborn, Jeff Bachant — 2001
• A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replicationCorrado Santocanale, John F.X. Diffley — 1998
• Regulation of DNA-replication origins during cell-cycle progressionKatsuhiko Shirahige, Yuji Hori, Katsuya Shiraishi — 1998
• The Schizosaccharomyces pombe rad3 checkpoint gene.Nicola J. Bentley, Douglas A. Holtzman, Gail Flaggs — 1996
• Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.Andrei Chabes, Bilyana Georgieva, Vladimir Domkin — 2003
• DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.Vaidehi Krishnan, Saurabh Nirantar, Karen Crasta — 2004
• Cell-cycle checkpoints and cancerMichael B. Kastan, Jiří Bártek — 2004
• A single S phase double-strand break influences replicon dynamics and triggers a Mre11-Tel1/ATM-mediated mechanism controlling terminal fork integrityYlli Doksani, Rodrigo Bermejo, Simona Fiorani — 2009
• DNA damage signalling guards against activated oncogenes and tumour progressionJiří Bártek, Jiřina Bártková, Jiří Lukáš — 2007
• Uninterrupted MCM2-7 function required for DNA replication fork progression.Karim Labib, José Antonio Tercero, John F.X. Diffley — 2000
• Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.Rodrigo Bermejo, Thelma Capra, Víctor González‐Huici — 2009
• Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.Yang David Lee, Stephen J. Elledge — 2006
• The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint*Zhongsheng You, Lindsay Kong, John W. Newport — 2002
• Yeast DNA Damage-inducible Rnr3 Has a Very Low Catalytic Activity Strongly Stimulated after the Formation of a Cross-talking Rnr1/Rnr3 Complex*Vladimir Domkin, Lars Thelander, Andrei Chabes — 2002
• The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.Mingxia Huang, Zheng Zhou, Stephen J. Elledge — 1998
• GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forksAgnieszka Gambus, Richard C. Jones, Alberto Sánchez‐Díaz — 2006
• ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow ZonesRita S. Cha, Nancy Kleckner — 2002

Cited by

• Replisome‐Cohesin Interfacing: A Molecular PerspectiveSara Villa‐Hernández, Rodrigo Bermejo — 2018
• Regulation of genome stability via Mcm2-7 ATPase active sites in Saccharomyces cerevisiaeSriram Vijayraghavan — 2014
• Regulation of Elg1 activity by phosphorylationDganit Shkedy, Nishant Singh, Keren Shemesh — 2015
• Ionizing Radiation-Induced DNA Damage, Response, and RepairWil L. Santivasi, Fen Xia — 2014
• Human CST abundance determines recovery from diverse forms of DNA damage and replication stressFeng Wang, Jason A. Stewart, Carolyn M. Price — 2014
• ATR prohibits replication catastrophe by preventing global exhaustion of RPA.Luis Toledo, Matthias Altmeyer, Maj‐Britt Rask — 2013
• Commentary: critical questions, misconceptions and a road map for improving the use of the lymphocyte cytokinesis-block micronucleus assay for in vivo biomonitoring of human exposure to genotoxic chemicals-a HUMN project perspective.Micheline Kirsch‐Volders, Stefano Bonassi, Siegfried Knasmueller — 2014
• Replisome Function During Replicative Stress Is Modulated by Histone H3 Lysine 56 Acetylation Through Ctf4Pierre Luciano, Pierre-Marie Dehé, Stéphane Audebert — 2015
• Homologous recombination maintenance of genome integrity during DNA damage toleranceFélix Prado — 2014
• The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiaeRithy Meas, Michael J. Smerdon, John J. Wyrick — 2015
• Checkpoint-dependent RNR induction promotes fork restart after replicative stressEsther Cabañas Morafraile, John F.X. Diffley, José Antonio Tercero — 2015
• Molecular mechanisms involved in initiation of the DNA damage responseKevin J Barnum, Matthew J. O’Connell — 2015
• Functions of Fun30 Chromatin Remodeler in Regulating Cellular Resistance to Genotoxic StressXin Bi, Qun Yu, Jasmine Siler — 2015
• The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stressesAnitha Suram, Utz Herbig — 2014
• Xbp1 Directs Global Repression of Budding Yeast Transcription during the Transition to Quiescence and Is Important for the Longevity and Reversibility of the Quiescent StateShawna Miles, Lihong Li, Jerry Davison — 2013
• Early Telomerase Inactivation Accelerates Aging Independently of Telomere LengthZhengwei Xie, Kyle A. Jay, Dana L. Smith — 2015
• Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cellsBabu V. Sajesh, Kirk J. McManus — 2015
• Bacterial Proliferation: Keep Dividing and Don't Mind the GapLuisa Laureti, Julien Demol, Robert P. Fuchs — 2015
• Checkpoint Regulation of Replication Forks: Global or Local?Divya Iyer, Nick Rhind — 2013
• Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells.Dominique Desplancq, Guillaume Freund, Sascha Conic — 2016

Related papers

• The G2-phase DNA-damage checkpoint.Matthew J. O’Connell, Nancy C. Walworth, Antony M. Carr — 2000
• Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replicationAndrea Ballabeni, Raffaella Zamponi, Jodene K. Moore — 2013
• Cell-cycle checkpoint kinases: checking in on the cell cycle.Nancy C. Walworth — 2000
• Redundant control of rereplication in fission yeastVidya Gopalakrishnan, Pamela Simancek, Christopher R. Houchens — 2001
• Phosphoregulation of Cdt1 in G2 and M phases prevents re-replication independently of GemininYizhuo Zhou, Pedro N. Pozo, Seeun Oh — 2018
• Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replicationStephanie K. Yanow, Zoi Lygerou, Paul Nurse — 2001
• Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation*Xiangzi Han, Franklin Mayca Pozo, Jacob N. Wisotsky — 2015
• Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.Ling Yin, Alexandra Monica Locovei, Gennaro D’Urso — 2008
• S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complexYuki Katou, Yutaka Kanoh, Masashige Bando — 2003