The biology of infertility: research advances and clinical challenges
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Summary
The past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility, but translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples.
- Type
- review
- Published
- 2008-11-01
- Cited by
- 944
- References
- 240
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969127101
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19235674
Keywords
Infertility, Biology, Reproduction, Human reproduction, Fertility
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Cited by
- Ontogenesis of Testis Development and Function in Humans
- DNA integrity, growth pattern, spindle formation, chromosomal constitution and imprinting patterns of mouse oocytes from vitrified pre-antral follicles.
- A rare synaptonemal complex protein 3 gene variant in unexplained female infertility.
- Early Versus Late Maturation Arrest: Reproductive Outcomes of Testicular Failure
- Next generation sequencing in women affected by nonsyndromic premature ovarian failure displays new potential causative genes and mutations.
- Novel Y-chromosomal microdeletions associated with non-obstructive azoospermia uncovered by high throughput sequencing of sequence-tagged sites (STSs)
- Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells.
- Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry
- Mouse models as tools in fertility research and male-based contraceptive development.
- Sindrome da insensibilità agli androgeni: classificazione e gestione clinica in età pediatrica e nell’adulto
- Genetics of male fertility.
- The clinical utility of the Halosperm assay and the development of a simplified method of human semen storage for the testing of sperm DNA fragmentation
- Роль диетотерапии в лечении и профилактике мужского идиопатического бесплодия
- Targeted Knockout of Beclin-1 Reveals an Essential Function in Ovary and Testis
- A computational approach to mechanistic and predictive toxicology of pesticides.
- In vitro maturation and in vitro fertilization of mouse oocytes and preimplantation embryo culture.
- Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice
- Étude de gènes impliqués dans la fertilité humaine à partir d'un modèle de souris interspécifiques recombinantes congéniques (IRCS)
- The Genetic and Molecular Etiologies of Two Spontaneous Mouse Models of Skeletal Dysplasia and Infertility.
- Identification et caractérisation de gènes impliqués dans l'infertilité masculine
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