Single-strand break repair and genetic disease
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Summary
The molecular mechanisms and organization of the DNA-repair pathways that remove single-strand breaks are reviewed and the connection between defects in these pathways and hereditary neurodegenerative disease are discussed.
- Type
- review
- Published
- 2008-08-01
- Cited by
- 1,017
- References
- 170
- Access
- Open access
- OpenAlex
- https://openalex.org/W1912177776
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39412478
Keywords
Biology, DNA damage, DNA repair, DNA, Genome instability
References
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- The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin
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- Transcription bypass or blockage at single-strand breaks on the DNA template strand: effect of different 3' and 5' flanking groups on the T7 RNA polymerase elongation complex.
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- DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination
- Characterization of plant XRCC1 and its interaction with proliferating cell nuclear antigen
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- Poly(ADP-ribosylation) reduces the steady-state level of breaks in DNA following treatment of human cells with alkylating agents.
- The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.
Cited by
- Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases
- APOPTOSIS INDUCED BY PERSISTENT SINGLE-STRAND BREAKS IN THE MITOCHONDRIAL GENOME: CRITICAL ROLE OF EXOG (5’ EXO/ENDONUCLEASE) IN THEIR REPAIR
- Development of a High-Throughput Fluorescence Polarization DNA Cleavage Assay for the Identification of FEN1 Inhibitors
- Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair
- An Improved Antibody-based Method to Detect Whole Genome Cytosine Methylation in Mouse Embryonic Fibroblasts
- Genome instability induced by structured DNA and replication fork restart
- A Genome-Wide Study of Homologous Recombination in Mammalian Cells Identifies RBMX, a Novel Component of the DNA Damage Response
- Interstrand Crosslinks - Induction and repair
- Ionising radiation-induced DNA damage response in marine mussels, Mytilus edulis
- Advances in understanding the coupling of DNA base modifying enzymes to processes involving base excision repair.
- Characterizing Ku’s Role as an AP lyase in Nonhomologous End Joining
- Investigating aprataxin function: roles in DNA single strand break repair and functional cellular effects
- Role of Tyrosyl-DNA Phosphodiesterase I (TDP1) as a Prognostic and Predictive Factor in Malignant Glioma
- Investigating the link between defective DNA end-processing and human neurological disease
- Visualizing chromosomal rearrangements caused by replication fork stalling in a single cell
- Function of Replication Protein A in DNA repair and cell checkpoints
- Functional genomic analysis of heat stress in Vitis vinifera
- In vitro and in vivo aspects of intrinsic radiosensitivity
- X-ray repair cross-complementing protein 1 associated multiprotein complexes in base excision repair
- DNA repair protein complexes, functionality and significance for repair efficiency and cell survival
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