Cellular senescence: when bad things happen to good cells
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Summary
Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.
- Type
- review
- Published
- 2007-09-01
- Cited by
- 4,423
- References
- 168
- OpenAlex
- https://openalex.org/W1970924670
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15664931
Keywords
Senescence, Cell biology, Cellular senescence, Biology, Endogeny
References
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- Organisation of complex nuclear domains in somatic mouse cells.
- The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
- A DNA damage checkpoint response in telomere-initiated senescence
Cited by
- Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cells
- Potential biomarkers of ageing
- New Insights into the Biology of Peritoneal Mesothelial Cells: The Roles of Epithelial-to-Mesenchymal Transition and Cellular Senescence
- p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
- Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases.
- Large CTG repeats trigger p16-dependent premature senescence in myotonic dystrophy type 1 muscle precursor cells.
- Supportive care in elderly cancer patients
- Telomerase and Human Disease: The Beginnings of the Ends?
- Oxidative stress‐dependent increase in ICAM‐1 expression promotes adhesion of colorectal and pancreatic cancers to the senescent peritoneal mesothelium
- Metabolic syndrome is a real disease and premalignant state induced by oncogenic stresses to block malignant transformation.
- Resveratrol e quercetina : avaliação da atividade antitumoral e dos mecanismos de ação em linhagens de gliomas in vitro e em um modelo de implante de gliomas in vivo
- Can biogerontologists and geriatricians unite to apply aging science to health care in the decade ahead?
- p38 MAPK and JNK Antagonistically Control Senescence and Cytoplasmic p16INK4A Expression in Doxorubicin-Treated Endothelial Progenitor Cells
- Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells
- Senescence and pre-malignancy: how do tumors progress?
- Wnt Antagonist SFRP1 Functions as a Secreted Mediator of Senescence
- Determinants of uterine aging: lessons from rodent models
- The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.
- Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53
- Dissecting the telomere-independent pathways underlying human cellular senescence
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