Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
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Summary
The function of IKKβ during the response to DNA damage, which promotes cell survival and DNA repair, and maintains cellular homeostasis is defined, is defined.
- Type
- dissertation
- Published
- 2013-04-04
- Cited by
- 25
- References
- 52
- OpenAlex
- https://openalex.org/W22614018
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:838334
Keywords
Food science, Xanthan gum, Chemistry, Materials science, Composite material
References
- The DNA damage response: putting checkpoints in perspective
- Cell-cycle checkpoints and cancer
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- Replication stress activates DNA polymerase alpha-associated Chk1
- HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents
- Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
- Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli
- The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis
- Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells
- The response of Parp knockout mice against DNA damaging agents.
- DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
- Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.
- Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: application to gamma-radiation and peroxynitrite.
- ATM: A mediator of multiple responses to genotoxic stress
- Effectiveness of IκB kinase inhibitors in murine colitis-associated tumorigenesis
- IKK and NF‐κB‐mediated regulation of Claspin impacts on ATR checkpoint function
- Doxorubicin Activates ATM-dependent Phosphorylation of Multiple Downstream Targets in Part through the Generation of Reactive Oxygen Species*
- ATM and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress
Cited by
- Non-conventional functions for NF-κB members: the dark side of NF-κB
- An Unconventional Role of BMP‐Smad1 Signaling in DNA Damage Response: A Mechanism for Tumor Suppression
- Regulation of anoikis by Deleted in Breast Cancer-1 (DBC1) through NF-κB
- Proteasome Inhibition Increases Recruitment of IκB Kinase β (IKKβ), S536P-p65, and Transcription Factor EGR1 to Interleukin-8 (IL-8) Promoter, Resulting in Increased IL-8 Production in Ovarian Cancer Cells*
- miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway.
- A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells
- New Approaches to Radiation Protection
- Hypoxic preconditioning decreases nuclear factor κB activity via Disrupted in Schizophrenia-1.
- Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma
- A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization
- Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition
- The Effect of IKKbeta on Estrogen Receptor Positive Breast Cancer Phenotypes
- Prognostic value of GRIM-19, NF-κB and IKK2 in patients with high-grade serous ovarian cancer.
- Context-Dependent Role of IKKβ in Cancer
- The IκB kinase complex is a regulator of mRNA stability
- HOXC10 promotes gastric cancer cell invasion and migration via regulation of the NF-κB pathway.
- Interaction between 3-Bromopyruvate and SC-514 in prostate cancer treatment
- Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p
- Determining the prognostic significance of IKKα in prostate cancer
- Regulation of anoikis by oncogenic pathways
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