The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability
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Summary
The specialized functions of Y family polymerases (Rev1, Polη, Polι and Polκ) and DNA polymerase ζ in lesion bypass, mutagenesis, and prevention of genome instability are described, the latter due to newly appreciated roles in DNA repair.
- Type
- article
- Published
- 2012-11-26
- Cited by
- 74
- References
- 264
- OpenAlex
- https://openalex.org/W23195997
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24021114
Keywords
Audit, Business administration, Business, Accounting
References
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- Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.
- Cellular functions of DNA polymerase zeta and Rev1 protein.
- The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
- The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair
- Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress*
- Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
- Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7 proteins.
- Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability
- Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.
- REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase
- Evidence for a second function for Saccharomyces cerevisiae Rev1p
- poliota, a remarkably error-prone human DNA polymerase.
- Overexpression of DNA polymerase β: a genomic instability enhancer process
- Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair
- Two‐polymerase mechanisms dictate error‐free and error‐prone translesion DNA synthesis in mammals
Cited by
- The importance of an interaction network for proper DNA polymerase ζ heterotetramer activity
- IDENTIFICATION OF NOVEL FANCD2 INTERACTING PROTEINS VIA IMMUNOPRECIPITATION AND MASS SPECTROMETRY
- RecBCD is required to Complete Chromosomal Replication: Implications for Double-Strand Break Frequencies and Repair Mechanisms
- Patterns and Mutational Signatures of Tandem Base Substitutions Causing Human Inherited Disease
- Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease.
- REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ
- Evolution of replicative DNA polymerases in archaea and their contributions to the eukaryotic replication machinery
- Breakthrough for a DNA break-preventer
- The Achievement of Shuttle Vector Techniques in Mammalian Cell Mutation Research
- The architecture of yeast DNA polymerase ζ
- The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis
- Structural insights into eukaryotic DNA replication
- Advances in understanding the complex mechanisms of DNA interstrand crosslink repair
- Stress and DNA repair biology of the Fanconi anemia pathway.
- Concurrent Nucleotide Substitution Mutations in the Human Genome Are Characterized by a Significantly Decreased Transition/Transversion Ratio
- DNA damage tolerance: a double-edged sword guarding the genome
- Conditional Genetic Interactions of RTT107, SLX4, and HRQ1 Reveal Dynamic Networks upon DNA Damage in S. cerevisiae
- Mechanism of aromatic amine carcinogen bypass by the Y-family polymerase, Dpo4
- The role of the Fanconi anemia pathway in sporadic head and neck cancer
- An Overview of Y-Family DNA Polymerases and a Case Study of Human DNA Polymerase η
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