Metabolic regulation of gene expression by histone lactylation
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Summary
The results suggest that an endogenous ‘lactate clock’ in bacterially challenged M1 macrophages turns on gene expression to promote homeostasis, and represents an opportunity to improve the understanding of the functions of lactate and its role in diverse pathophysiological conditions, including infection and cancer.
- Type
- article
- Published
- 2019-10-01
- Cited by
- 3,762
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2982216374
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:204848816
Keywords
Warburg effect, Histone, Biology, Cell biology, Epigenetics
References
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Cited by
- Histone lactylation links metabolism and gene regulation
- Lactylation drives resolution
- Identification of dual histone modification-binding protein interaction by combining mass spectrometry and isothermal titration calorimetric analysis
- Non-Enzymatic Lysine Lactoylation of Glycolytic Enzymes
- An outer membrane protease OmpT based strategy for simplified analysis of histone post-translational modifications by mass spectrometry.
- On macrophage diversity and inflammatory metabolic timers
- The hypoxia–lactate axis tempers inflammation
- Lactate: Fueling the fire starter
- Glutamine Links Obesity to Inflammation in Human White Adipose Tissue.
- Homeorhesis in Waddington's landscape by epigenetic feedback regulation
- Histone Lactylation: A New Role for Glucose Metabolism.
- Exercise immunology: Future directions
- Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response
- Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells
- The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma
- Photo Cross‐Linking Probes Containing ϵ‐N‐Thioacyllysine and ϵ‐N‐Acyl‐(δ‐aza)lysine Residues†
- Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism
- Metabolic regulation of epigenetic remodeling in immune cells
- USP9X deubiquitinase couples the pluripotency network and cell metabolism to regulate ESC differentiation potential
- Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation
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