The Glycolytic Switch in Tumors: How Many Players Are Involved?
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Summary
Current information is summarized on several main mediators and their possible mechanisms for triggering the Warburg effect, which promotes tumorigenesis and malignancy progression in cancers.
- Type
- review
- Published
- 2017-09-20
- Cited by
- 202
- References
- 170
- Access
- Open access
- OpenAlex
- https://openalex.org/W2759858864
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1441093
Keywords
Warburg effect, Glycolysis, Anaerobic glycolysis, Carcinogenesis, Reprogramming
References
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- Contribution of the Phosphorylable Complex I in the Growth Phase-Dependent Respiration of C6 Glioma Cells in Vitro
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- PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop
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- SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
- IGF1 regulates PKM2 function through Akt phosphorylation
- Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma
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- PTTG regulates the metabolic switch of ovarian cancer cells via the c-myc pathway
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- Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer
- Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
- Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
Cited by
- Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression
- Nrf2-Mediated Metabolic Reprogramming in Cancer
- Hallmark tumor metabolism becomes a validated therapeutic target
- In-vivo topical mucosal delivery of a fluorescent deoxy-glucose delineates neoplasia from normal in a preclinical model of oral epithelial neoplasia
- Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma.
- Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization
- Oviductus ranae protein hydrolysate (ORPH) inhibits the growth, metastasis and glycolysis of HCC by targeting miR-491-5p/PKM2 axis.
- Ginsenoside 20(S)-Rg3 Prevents PKM2-Targeting miR-324-5p from H19 Sponging to Antagonize the Warburg Effect in Ovarian Cancer Cells
- Metabolomics study of oral cancers
- Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes
- Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases
- Cellular Consequences of Arginine Methylation
- Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia-Reperfusion Injury.
- Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma
- Gcn5 and Ubp8 dependent ubiquitylation affects glycolysis in yeast
- Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate
- Expression of Alpha-Enolase (ENO1), Myc Promoter-Binding Protein-1 (MBP-1) and Matrix Metalloproteinases (MMP-2 and MMP-9) Reflect the Nature and Aggressiveness of Breast Tumors
- MicroRNA Networks Modulate Oxidative Stress in Cancer
- Crucial Players in Glycolysis: Cancer Progress.
- Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer
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