Non-Enzymatic Lysine Lactoylation of Glycolytic Enzymes
Explore this paper's citation graph
Summary
Using an alkyne-tagged methylglyoxal analog, it is shown that these modifications are enriched on glycolytic enzymes and regulate glycolysis.
- Type
- article
- Published
- 2019-11-20
- Cited by
- 375
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W2990296073
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:208298208
Keywords
Lysine, Enzyme, Biochemistry, Glycolysis, Chemistry
References
- An Azido-Biotin Reagent for Use in the Isolation of Protein Adducts of Lipid-derived Electrophiles by Streptavidin Catch and Photorelease*
- Genome engineering using CRISPR-Cas9 system.
- Functional lysine modification by an intrinsically reactive primary glycolytic metabolite
- Sirtuins as regulators of metabolism and healthspan
- Proteomic characterization of wheat amyloplasts using identification of proteins by tandem mass spectrometry
- Isolation of glyoxalase II from two different compartments of rat liver mitochondria. Kinetic and immunochemical characterization of the enzymes.
- Activity, regulation, copy number and function in the glyoxalase system.
- Regulation of Cellular Metabolism by Protein Lysine Acetylation
- Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: the human proteome.
- Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice
- Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search.
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- Widespread and Enzyme-independent Nϵ-Acetylation and Nϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix*♦
- Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics
- Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
- Quantitative Analysis and Discovery of Lysine and Arginine Modifications (QuARKMod)
- Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II
- Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction
- Glyoxalase 2 drives tumorigenesis in human prostate cells in a mechanism involving androgen receptor and p53‐p21 axis
- Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target
Cited by
- Dicarbonyl derived post-translational modifications: chemistry bridging biology and aging-related disease.
- Compartmentalised acyl-CoA metabolism and roles in chromatin regulation
- Advances into understanding metabolites as signaling molecules in cancer progression
- The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity
- Interaction Profiling Methods to Map Protein and Pathway Targets of Bioactive Ligands
- Dietary restriction of amino acids for Cancer therapy
- Non-enzymatic covalent modifications: a new link between metabolism and epigenetics
- ALKBH7 mediates necrosis via rewiring of glyoxal metabolism
- The sunless tanning agent dihydroxyacetone induces stress response gene expression and signaling in cultured human keratinocytes and reconstructed epidermis
- Catalytic activity regulation through post-translational modification: the expanding universe of protein diversity
- Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
- Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues
- Discovery of post-translational modifications in immunometabolism by chemical proteomics.
- Electrophile Modulation of Inflammation: A Two-Hit Approach
- Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling
- An Enolase Inhibitor for the Targeted Treatment of ENO1-Deleted Cancers
- Lysine metabolism conveys kidney protection in hypertension
- Protein lactylation induced by neural excitation
- The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases
- Sirtuin 2 Regulates Protein LactoylLys Modifications
Related papers
- ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ
- DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION
- A GEOMETRIC MEAN IN THE FURUTA INEQUALITY
- ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
- Darstellung perhalogenierter Dimethyldisulfane durch photochemische Reaktion von CSF2 und CSFCI mit Sulfenylbromiden bzw. ‐chloriden
- Influence of glucose and inhibitors of glycolysis on release of total proteins and enzymes from human leukocytes.