Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer
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Summary
The results mechanistically imply that clinical outcome in breast cancer could simply be determined by epigenetics and energy metabolism, rather than by the accumulation of specific “classical” gene mutations.
- Type
- article
- Published
- 2011-04-15
- Cited by
- 354
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W2004045970
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:207511938
Keywords
Biology, Metastasis, Breast cancer, Cancer, Cancer research
References
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- Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype
- Ketones and lactate “fuel” tumor growth and metastasis
- Lactic acidosis: a metabolic complication of extensive metastatic cancer.
- The autophagic tumor stroma model of cancer
- Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.
- Neurons and Neuronal Stem Cells Survive in Glucose-Free Lactate and in High Glucose Cell Culture Medium During Normoxia and Anoxia
- CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation
- Understanding the "lethal" drivers of tumor-stroma co-evolution
- Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation
- Adaptation of energy metabolism in breast cancer brain metastases.
- Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary.
- Lactate: mirror and motor of tumor malignancy.
- Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
- Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
- Type B lactic acidosis and metastatic breast cancer
Cited by
- Metabolic Symbiosis in Cancer: Refocusing the Warburg Lens
- Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
- Cancer: an epigenetic landscape.
- The roles of translocator protein (TSPO) and adenine nucleotide translocase 2 (ANT2) in breast cancer development and progression
- Vorstellungen zur Therapie von Malignomen mit Krebsdiäten
- Autophagy and its function in radiosensitivity
- Inflammation, advancing age and nutrition
- Cancer Metabolism: New Validated Targets for Drug Discovery
- Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells
- Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
- Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
- Sirtuins and the metabolic hurdles in cancer
- Diabetes, cancer, and metformin: connections of metabolism and cell proliferation
- A Novel Soluble Peptide with pH-Responsive Membrane Insertion.
- Autophagy in stem and progenitor cells
- Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin
- Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells
- Alternative Medizin bei Tumorerkrankungen
- Starvation of cancer via induced ketogenesis and severe hypoglycemia.
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