Oncogenic alterations of metabolism and the Warburg effect
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Summary
This work has suggested that adaptive responses through the induction of the hypoxia-inducible factor 1 (HIF-1) and cell autonomous changes that affect the level of Hif-1 or activation of the AKT or MYC oncogenes could all contribute to the aerobic glycolytic cancer phenotype.
- Type
- article
- Published
- 2005-06-01
- Cited by
- 29
- References
- 45
- OpenAlex
- https://openalex.org/W2056444349
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:85010845
Keywords
Warburg effect, Anaerobic glycolysis, Glycolysis, Biology, Cell biology
References
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Cited by
- Antitumor effect of blister beetles: an ethno-medicinal practice in Karbi community and its experimental evaluation against a murine malignant tumor model.
- The application of metabolic network analysis in understanding and targeting metabolism for drug discovery
- Apoptosis of Dalton’s lymphoma due to in vivo treatment with emodin is associated with modulations of hydrogen peroxide metabolizing antioxidant enzymes
- Metal Cu(II) and Zn(II) bipyridyls as inhibitors of lactate dehydrogenase
- Activation of p53 mediated glycolytic inhibition-oxidative stress-apoptosis pathway in Dalton's lymphoma by a ruthenium (II)-complex containing 4-carboxy N-ethylbenzamide.
- Dimethyl sulfoxide activates tumor necrosis factorα-p53 mediated apoptosis and down regulates D-fructose-6-phosphate-2-kinase and lactate dehydrogenase-5 in Dalton's lymphoma in vivo.
- Tetraspanins affect myeloma cell fate via Akt signaling and FoxO activation.
- Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells
- A glucose derivative as natural alternative to the cyclohexane‐1,2‐diamine ligand in the anticancer drug oxaliplatin?
- Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism.
- Targeting Glucose Metabolism: An Emerging Concept for Anticancer Therapy
- Fingerprinting of metabolic states by NAD(P)H fluorescence lifetime spectroscopy in living cells: A review
- Regression of Dalton’s lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide as ligand
- Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis.
- Lymphoma affects enzymes and protein profile of non-lymphatic tissues in mice
- The Warburg effect: a balance of flux analysis
- Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells.
- Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2
- Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion
- The gamma-tubulin meshwork as a therapeutic target
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