Principles of bioactive lipid signalling: lessons from sphingolipids
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Summary
An understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action is required to understand the mechanisms of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking.
- Type
- review
- Published
- 2008-02-01
- Cited by
- 3,326
- References
- 119
- OpenAlex
- https://openalex.org/W1966452335
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8692993
Keywords
Sphingolipid, Ceramide, Lipid signaling, Sphingomyelin, Cell biology
References
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- The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind*
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- Glucosylceramide synthase and glycosphingolipid synthesis.
- Glycosphingolipidoses: Beyond the enzymatic defect
Cited by
- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease
- S1P Control of Endothelial Integrity
- Sphingomyelin and its role in cellular signaling.
- Ceramide and mitochondria in ischemic brain injury.
- The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.
- Designer enzymes for glycosphingolipid synthesis by directed evolution.
- DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity*
- Radiation countermeasure agents: an update
- Intestinal absorption of dietary maize glucosylceramide in lymphatic duct cannulated rats
- Blood sphingolipidomics in healthy humans: impact of sample collection methodology
- Ceramide synthases: reexamining longevity.
- Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine
- Glycosphingolipid Modification: Structural Diversity, Functional and Mechanistic Integration of Diabetes
- Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression
- Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism
- Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin
- Revised stereochemistry of ceramide-trafficking inhibitor HPA-12 by X-ray crystallography analysis.
- Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics
- Review: novel insights into the regulation of vascular tone by sphingosine 1-phosphate.
- The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas
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