DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity*
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Summary
This study indicates that TG is not likely to be a toxic lipid species directly, but rather it is a feature of physiologic hypertrophy and may serve a cytoprotective role in lipid overload states and induction of DGAT1 could be beneficial in the setting of excess heart accumulation of toxic lipids.
- Type
- article
- Published
- 2009-09-24
- Cited by
- 239
- References
- 55
- OpenAlex
- https://openalex.org/W19778901
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24745150
Keywords
Geology
References
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- HIGH‐FAT DIET PREVENTS CARDIAC HYPERTROPHY AND IMPROVES CONTRACTILE FUNCTION IN THE HYPERTENSIVE DAHL SALT‐SENSITIVE RAT
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- Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training.
- Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
- Lipotoxicity: when tissues overeat
- Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
Cited by
- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease
- Heart sphingolipids in health and disease.
- Mechanisms and consequences of hypertriglyceridemia and cellular lipid accumulation in chronic kidney disease and metabolic syndrome.
- Sphingolipid metabolism and analysis in metabolic disease.
- Subcellular distribution of lipid metabolising enzymes in human skeletal muscle
- Intracellular lipid accumulation and shift during diabetes progression
- Altérations du métabolisme cardiaque associées à des désordres génétiques de l’oxydation des acides gras à chaîne longue chez la souris
- The Evolving Understanding of the Contribution of Lipid Metabolism to Diabetic Kidney Disease
- Cardiomyopathy and muscle insulin resistance in type 2 diabetes : craving for sugars, or dying for fat?
- Regulation of Metabolic Stress-Induced snoRNAs
- Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP
- Genetic and functional studies of MTTP and PLIN2 in relation to metabolic and cardiac dysfunction
- Fatty heart, cardiac damage, and inflammation.
- Metabolic imaging in obesity: underlying mechanisms and consequences in the whole body
- Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats
- Sphingolipid regulators of cellular dysfunction in Type 2 diabetes mellitus: a systems overview
- Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress
- Cardiac Metabolism and Its Interactions with Contraction, Growth, and Survival of the Cardiomyocte
- Lipid Metabolism and Toxicity in the Heart
- Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.
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