The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas
Explore this paper's citation graph
Summary
expression of the sphingosine signaling pathway components was influenced by radio/radiochemotherapy in distinct ways and S1P5 is identified as an independent prognostic factor in multivariate analysis, and this pathway promises to be a candidate for targeted therapies.
- Type
- article
- Published
- 2014-06-06
- Cited by
- 43
- References
- 40
- OpenAlex
- https://openalex.org/W24903384
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15950841
Keywords
Animal rights, Business, Political science, Law
References
- Sphingosine‐1‐phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival
- Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal‐regulated kinase
- RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues.
- Principles of bioactive lipid signalling: lessons from sphingolipids
- FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.
- Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy.
- A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis*
- Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
- Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim*
- Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes.
- Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability
- Sphingosine-1-phosphate: an enigmatic signalling lipid
- FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.
- Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell‐cycle entry and apoptosis
- Early induction of apoptosis in androgen‐independent prostate cancer cell line by FTY720 requires caspase‐3 activation
- Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.
- Cell surface receptors in lysophospholipid signaling.
- FTY720 modulates human oligodendrocyte progenitor process extension and survival
- Sphingosine Kinase-1 Expression Correlates With Poor Survival of Patients With Glioblastoma Multiforme: Roles of Sphingosine Kinase Isoforms in Growth of Glioblastoma Cell Lines
- Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model
Cited by
- Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer
- Targeting autophagy to sensitive glioma to temozolomide treatment
- Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme
- Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
- Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors
- Sphingosine Kinase Inhibitors as Maintenance Therapy of Glioblastoma After Ceramide-Induced Response.
- Malignant Brain Tumors: Death Sentence, No Mercy
- Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.
- Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
- Augmented expression of RUNX1 deregulates the global gene expression of U87 glioblastoma multiforme cells and inhibits tumor growth in mice
- Comparative analysis of the effects of a sphingosine kinase inhibitor to temozolomide and radiation treatment on glioblastoma cell lines
- Cerebrovascular Angiogenic Reprogramming upon LRP1 Repression: Impact on Sphingosine-1-Phosphate-Mediated Signaling in Brain Endothelial Cell Chemotactism
- The Crossroads of Neural Stem Cell Development and Tumorigenesis
- “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer
- Sphingosine 1-Phosphate (S1P) Signaling in Glioblastoma Multiforme—A Systematic Review
- New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection
- Sphingolipid-mediated calcium signaling and its pathological effects.
- A bidirectional crosstalk between glioblastoma and brain endothelial cells potentiates the angiogenic and proliferative signaling of sphingosine-1-phosphate in the glioblastoma microenvironment.
- Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma
- Bioactive Sphingolipids as Biomarkers Predictive of Disease Severity and Treatment Response in Cancer: Current Status and Translational Challenges
Related papers
No related papers recorded.