Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
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Summary
A role of sphingosine kinase type 1 activation in proinflammatory signalling and of SPHK1 basal activity in survival of A549 lung carcinoma cells is demonstrated.
- Type
- article
- Published
- 2005-10-01
- Cited by
- 136
- References
- 50
- OpenAlex
- https://openalex.org/W1964520752
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27059469
Keywords
Sphingosine kinase 1, Proinflammatory cytokine, Sphingosine kinase, Sphingosine, Cell biology
References
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Cited by
- Bioactive sphingolipids in the modulation of the inflammatory response.
- Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.
- Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching
- Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway.
- Therapeutic potential of targeting SK1 in human cancers.
- Sphingolipid metabolizing enzymes as novel therapeutic targets.
- Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1.
- Metabolomic profiling in inflammatory bowel disease
- Rôle de la voie sphingosine kinase/sphingosine 1-phosphate dans le contrôle de la division cellulaire
- Cancer Treatment Strategies Targeting Sphingolipid Metabolism
- Creating a protein-protein interaction network for alpha-synuclein
- Die Bedeutung des Sphingolipidstoffwechsels für die Generierung von inflammatorischen und fibrotischen Mediatoren in renalen Mesangiumzellen
- Sphingosine-1-phosphate enhances IL-1beta-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts.
- Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages.
- Principles of bioactive lipid signalling: lessons from sphingolipids
- Development of a sphingosine kinase 1 specific small-molecule inhibitor.
- Role of sphingolipids in arachidonic acid metabolism.
- Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response.
- Effect of L-cycloserine on cellular responses mediated by macrophages and T cells.
- An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma
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