Role of the G-Protein-Coupled Receptor GPR12 as High-Affinity Receptor for Sphingosylphosphorylcholine and Its Expression and Function in Brain Development
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Summary
It is hypothesize that sphingosylphosphorylcholine, most likely by interaction with GPR12, has positive effects on the differentiation and maturation of postmitotic neurons and that it may also influence the proliferation of neuronal precursor cells.
- Type
- article
- Published
- 2003-02-01
- Cited by
- 105
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1879935490
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5515941
Keywords
Cell biology, Pertussis toxin, Receptor, Biology, Chinese hamster ovary cell
References
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- Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids 1
- Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide.
- Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
- Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin‐like receptor 1 (SLC‐1)
- Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4*
- Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5*
- The germ cell nuclear factor mGCNF is expressed in the developing nervous system.
- Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology.
- Lysophospholipid receptor nomenclature.
- Involvement of a Gardos-type potassium channel in head activator-induced mitosis of BON cells.
- Molecular cloning of a novel putative G protein‐coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system
- Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
- Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A
- The Signal Peptide of the G Protein-coupled Human Endothelin B Receptor Is Necessary for Translocation of the N-terminal Tail across the Endoplasmic Reticulum Membrane*
- Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.
- A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor.
Cited by
- Cross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors
- Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors
- Lysophospholipide induzieren Calcium- und pH-Änderungen in muriner Mikroglia
- Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors
- Principles of bioactive lipid signalling: lessons from sphingolipids
- G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice.
- Ligand screening system using fusion proteins of G protein-coupled receptors with G protein alpha subunits.
- GPR12 Selections of the metabolites from an endophytic Streptomyces sp. Asociated with Cistanches deserticola
- A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands.
- Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.
- Two New 5-Hydroxy-2-pyrone Derivatives Isolated from a Marine-derived Fungus Aspergillus flavus
- Identification and characterisation of GPR100 as a novel human G‐protein‐coupled bradykinin receptor
- A neuroscientist's guide to lipidomics
- Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.
- Monogenic neurological disorders of sphingolipid metabolism.
- The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37
- Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway.
- Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
- The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells
- G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.
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