The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.
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Summary
Analysis of regulatory mechanisms controlling SK1 activity and function suggests that SK1 is a CCT/TRiC substrate, and that this chaperonin facilitates folding of newly translated SK1 into its mature active form.
- Type
- article
- Published
- 2009-04-01
- Cited by
- 21
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W18775504
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28600649
Keywords
Philosophy, Humanities
References
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- Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
- A yeast TCP-1-like protein is required for actin function in vivo.
- The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
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- Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity*
- Sphingosine kinase-1 – a potential therapeutic target in cancer
- An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes.
- The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin
- Sphingosine-1-phosphate: an enigmatic signalling lipid
- Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation
- Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
- The interaction network of the chaperonin CCT
- Stem cell regulation by lysophospholipids.
- Sphingosine Kinase 1 (SPHK1) Is Induced by Transforming Growth Factor-β and Mediates TIMP-1 Up-regulation*
Cited by
- Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway.
- Microtubules, Acetylation, and MEC-3 Regulated Genes in C. Elegans Mechanosensations
- Regulation of Nuclear Factor κB (NF-κB) Transcriptional Activity via p65 Acetylation by the Chaperonin Containing TCP1 (CCT)
- Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin
- Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1*
- Post-translational regulation of sphingosine kinases.
- Sphingosine Kinase: Role in Regulation of Bioactive Sphingolipid Mediators in Inflammation
- Polyglutamined expanded androgen receptor interacts with chaperonin CCT.
- Sphingosine kinase 1 isoform-specific interactions in breast cancer.
- Identification of mechanisms controlling the transcriptional activity of nuclear factor kappa B (NF-κB) p65/RelA
- Identification and characterization of Laodelphax striatellus (Insecta: Hemiptera: Delphacidae) neutral sphingomyelinase
- TRiC enhances retrograde axonal transport by modulating tau phosphorylation
- Molecular Mechanisms of Regulation of Sphingosine Kinase 1
- Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma
- Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.
- The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation.
- Effects of intrauterine devices on proteins in the uterine lavage fluid of mares.
- Ginkgolide B Targets and Inhibits Creatine Kinase B to Regulate the CCT/TRiC-SK1 Axis and Exerts Pro-Angiogenic Activity in Middle Cerebral Artery Occlusion Mice.
- Sphingosine Kinases: Biochemistry, Regulation, and Roles
- Sphingoproteomics: Proteomic Strategies to Examine Sphingolipid Biology
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