ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Explore this paper's citation graph
Summary
The discovery of ALKBH5 as another mammalian demethylase that oxidatively reverses m6A in mRNA in vitro and in vivo strongly suggests that the reversible m6A modification has fundamental and broad functions in mammalian cells.
- Type
- article
- Published
- 2012-11-21
- Cited by
- 3,134
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W2165547003
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41712459
Keywords
Biology, Demethylase, RNA, Cell biology, Fertility
References
- Methylations of adenosine residues (m6A) in pre-mRNA are important for formation of late simian virus 40 mRNAs.
- Fine-tuning of RNA functions by modification and editing
- Visualisation of ribosomal RNA (rRNA) synthesis in eukaryotic cells in culture
- Serine‐arginine protein kinases: a small protein kinase family with a large cellular presence
- Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.
- Effect of undermethylation on mRNA cytoplasmic appearance and half-life
- Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing
- Methylated bases of ribosomal ribonucleic acid from HeLa cells.
- Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
- Nucleotides adjacent to N6-methyladenosine in maize poly(A)-containing RNA
- Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.
- Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
- In vitro production of fertile sperm from murine spermatogonial stem cell lines.
- Reversal of DNA alkylation damage by two human dioxygenases
- The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
- Gene expression patterns associated with infertility in humans and rodent models.
- Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
- Sequence specificity of the human mRNA N6-adenosine methylase in vitro.
- Role of selenium in spermatogenesis: Differential expression of cjun and cfos in tubular cells of mice testis
- The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.
Cited by
- ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
- Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.
- Emerging roles of RNA modification: m(6)A and U-tail.
- Update: Mechanisms underlying N6-methyladenosine modification of eukaryotic mRNA
- m6A modulates neuronal functions and sex determination in Drosophila
- Arabidopsis m6A demethylase activity modulates viral infection of a plant virus and the m6A abundance in its genomic RNAs
- The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5
- Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
- Reduced nucleic acid methylation impairs meiotic maturation and developmental potency of pig oocytes.
- N6-methyladenosine (m6A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review
- The untranslated regions of mRNAs in cancer
- m6A-seq analysis of microRNAs reveals that the N6-methyladenosine modification of miR-21-5p affects its target expression.
- The role of N6-methyladenosine (m6A) in kidney diseases
- Factor Inhibiting HIF's (FIH) Structure Controls O2 Activation and Reactivity
- The Arabidopsis epitranscriptome.
- Soy Glyceollins Regulate Transcript Abundance in the Female Mouse Brain
- RNA Abundance Analysis: Methods and Protocols
- The epigenetics of aging and neurodegeneration
- Circadian rhythm of RNA N6-methyladenosine and the role of cryptochrome.
- Transcriptome-Wide Mapping of N⁶-Methyladenosine by m⁶A-Seq.
Related papers
- ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
- KDM5B protein expressed in viable and fertile ΔARID mice exhibit no demethylase activity
- Biological roles of LSD1 beyond its demethylase activity
- When Is a Demethylase Not a Demethylase?
- Inhibition of demethylases by GSK-J1/J4
- Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.
- Making a 6mA demethylase
- Suppression of hepatic DMN demethylase activity by nitrososarcosine and other nitrosamines.
- Evidence of a Demethylase-Independent Role for the H3K4-Specific Histone Demethylases in Aspergillus nidulans and Fusarium graminearum Secondary Metabolism
- Lysine demethylase 5B (KDM5B): A key regulator of cancer drug resistance