Suppression of hepatic DMN demethylase activity by nitrososarcosine and other nitrosamines.
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Summary
Nitrososarcosine rapidly inhibited DMN dem methylase activity, and induced statistically significant inhibitory effects at doses far below threshold levels for inhibition of aminopyrine demethylase.
- Type
- article
- Published
- 1976-12-15
- Cited by
- 6
- References
- 8
- OpenAlex
- https://openalex.org/W2003221198
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44466816
Keywords
Demethylase, Chemistry, In vivo, Pharmacology, Biochemistry
References
- The acute toxic action of dimethylnitrosamine on liver cells.
- The preparation and properties of some nitrosamino acids.
- Paradoxical effects of piperonyl butoxide on the kinetics of mouse liver microsomal enzyme activity.
- In vitro versus in vivo metabolic activation of mutagens.
- Carcinogenic nitroso compounds.
- The decomposition and toxicity of dialkylnitrosamines in rats.
- Effect of aminoacetonitrile on the metabolism of dimethylnitrosamine and methylation of RNA during liver carcinogenesis.
- Cellular injury and carcinogenesis. Inhibition of metabolism of dimethylnitrosamine by aminoacetonitrile.
Cited by
- Effect of chronic alcohol consumption on tumor incidence due to dimethylnitrosamine administration
- Inhibition of rat hepatic dimethylnitrosamine demethylase by cyclic and acyclic nitrosamines and secondary amines
- Subchronic effects of piperonyl butoxide on carcinogen metabolism in hamster liver
- Inhibition of two rat hepatic microsomal drug-metabolizing enzymes by a carcinogenic N-nitrosated pesticide: N-nitrosocarbaryl.
- Urinary exposure of N-nitrosamines and associated risk of esophageal cancer in a high incidence area in China.
- Risk assessment of N‐nitrosamines in food
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