Biological roles of LSD1 beyond its demethylase activity
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Summary
It is anticipated that these non-canonical functions of LSD1 will arouse the consideration that extending the LSD1-based drug discovery to targeting LSD1 protein interactions non-catalytically, not only its demethylase activity, may be a novel strategy for cancer prevention.
- Type
- review
- Published
- 2020-03-19
- Cited by
- 93
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W3011810360
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:213187478
Keywords
Demethylase, Computational biology, Chemistry, Biology, Histone
References
- LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control
- The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities
- A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
- Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage
- A Systematic Review of Histone Lysine‐Specific Demethylase 1 and Its Inhibitors
- Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b
- Opposing LSD1 complexes function in developmental gene activation and repression programmes
- Roles of F-box proteins in cancer
- The histone LSD1 demethylase in stemness and cancer transcription programs.
- LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation
- Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression
- Lysine Specific Demethylase 1 has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity
- Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer
- Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells.
- A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling Through Multivalent Reading of Nucleosome Codes
- Androgen Action and Metabolism in Prostate Cancer
- Cyclophosphamide Perturbs Cytosine Methylation in Jurkat-T Cells through LSD1-mediated Stabilization of DNMT1 Protein
- Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer
- Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma
- A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation
Cited by
- Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells
- Riboflavin Deficiency—Implications for General Human Health and Inborn Errors of Metabolism
- Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
- Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).
- Tranylcypromine based LSD1 inhibitor: Summary and Prospective.
- Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation
- Target separation and antitumor metastasis activity of sesquiterpene-based lysine-specific demethylase 1 inhibitors from zedoary turmeric oil.
- miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression
- LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level
- Lysine-specific demethylase 1 inhibition enhances autophagy and attenuates early-stage post-spinal cord injury apoptosis
- MicroRNA-325 facilitates atherosclerosis progression by mediating the SREBF1/LXR axis via KDM1A.
- Gene Transcription as a Therapeutic Target in Leukemia
- Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer
- MicroRNA-137-mediated inhibition of lysine-specific demethylase-1 prevents against rheumatoid arthritis in an association with the REST/mTOR axis
- Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression
- The Role of Lysine-Specific Demethylase 1 (LSD1) in Shaping the Endothelial Inflammatory Response.
- Tumor Suppressor FBXW7 and Its Regulation of DNA Damage Response and Repair
- Therapeutic potential of targeting LSD1/ KDM1A in cancers.
- LSD1: Expanding Functions in Stem Cells and Differentiation
- Genome Instability in Multiple Myeloma: Facts and Factors
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