Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Summary
This study raises the possibility that DNA demethylation may occur through Tet-catalyzed oxidation followed by decarboxylation, and identifies two previously unknown cytosine derivatives in genomic DNA as the products of Tet proteins.
- Type
- article
- Published
- 2011-07-21
- Cited by
- 3,334
- References
- 19
- OpenAlex
- https://openalex.org/W1997453048
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206536184
Keywords
5-Methylcytosine, 5-Hydroxymethylcytosine, DNA demethylation, DNA methylation, DNA
References
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- Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
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- The colorful history of active DNA demethylation.
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- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
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Cited by
- APC and DNA demethylation in cell fate specification and intestinal cancer.
- Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos
- 5-Methylcytosine and 5-Hydroxymethylcytosine Spatiotemporal Profiles in the Mouse Zygote
- Epigenetic Mechanisms of Depression and Antidepressants Action
- Epigenetics in Sports
- Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis
- Gadd45 proteins: key players of repair-mediated DNA demethylation.
- Why do primordial germ cells migrate through an embryo and what does it mean for biological evolution?
- Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.
- [TET-OGT interaction potentiates transcription by regulating histone H3 methylation].
- DNA methylation and hydroxymethylation in stem cells
- Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells
- Control of Foxp3 stability through modulation of TET activity
- The Impact of DNA Methylation in Hematopoietic Malignancies
- Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue
- Novel Therapies for Acute Myeloid Leukemia: Are We Finally Breaking the Deadlock?
- Integrin α6β4 Upregulates Amphiregulin and Epiregulin through Base Excision Repair-Mediated DNA Demethylation and Promotes Genome-wide DNA Hypomethylation
- Genome-wide 5-hydroxymethylcytosine patterns in human spermatogenesis are associated with semen quality.
- [Role and alterations of DNA methylation during the aging and cancer].
- DNA Methylation in Animal Models of Psychosis
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