Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Explore this paper's citation graph
Summary
Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
- Type
- review
- Published
- 2003-03-01
- Cited by
- 6,280
- References
- 190
- OpenAlex
- https://openalex.org/W1967064280
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17270515
Keywords
Epigenetics, Biology, DNA methylation, Multicellular organism, Epigenetic regulation of neurogenesis
References
- The 5-methylcytosine content of DNA from human tumors.
- Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2.
- Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
- The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC).
- Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications
- Gene silencing quantitatively controls the function of a developmental trans-activator.
- The role of micronutrients in DNA synthesis and maintenance.
- X inactivation, differentiation, and DNA methylation.
- Above and Within the Genome: Epigenetics Past and Present
- Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
- Developmental biology. Don't clone humans!
- Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
- Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
- Methylation dynamics, epigenetic fidelity and X chromosome structure.
- Aberrant methylation of donor genome in cloned bovine embryos
- The fundamental role of epigenetic events in cancer
- Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila
- Ageing: Cloning of mice to six generations
- X-chromosome inactivation: counting, choice and initiation
- Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
Cited by
- Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing.
- Establishment and maintenance of DNA methylation patterns in mammals.
- Project 1: “Towards a prophylactic Epstein Barr Virus (EBV) vaccine to prevent EBV -associated malignancies and infectious mononucleosis” and project 2: “Analysing the transcriptional response to histone deacetylase inhibitors treatment in normal and cancer cell lines”
- Use of SNP-arrays for ChIP assays: computational aspects.
- Nutrigenomics: Looking to DNA for nutrition advice
- Mechanisms linking in utero stress to altered offspring behaviour.
- DNA methylation analysis of germ cells by using bisulfite-based sequencing methods.
- Perturbation of epigenetic status by toxicants.
- CpG island methylator phenotype in cancer
- Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia?
- Epigenetics and behavioural plasticity: drosophila euchromatin histone metiltransferase and foraging
- Genomic imprinting and methylation: epigenetic canalization and conflict.
- Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection
- Intra- and interindividual epigenetic variation in human germ cells.
- Rab33A: characterization, expression, and suppression by epigenetic modification.
- Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
- Why are immigrants at increased risk for psychosis? Vitamin D insufficiency, epigenetic mechanisms, or both?
- Schizophrenia: a common disease caused by multiple rare alleles
- Personalised nutrition: status and perspectives
- Are postnatal hemangioblasts generated by dedifferentiation from committed hematopoietic stem cells?
Related papers
- Ontological Butchery: Organism Concepts and Biological Generalizations
- Нормальное Старение Как Следствие Реакции Управляющих Систем Организма На Внешние Сигналы, Не Способствующие Его Полному Самоподдержанию I. Биологические Предпосылки
- [The cell theory. Progress in studies on cell-cell communications].
- Cells in the system of multicelular organism from positions of non-linear dynamics