Autophagy machinery in the context of mammalian mitophagy.
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Summary
This "two-step model" may be applied to other selective types of autophagy, as damaged mitochondria first associate with the autophagosome formation site together with upstreamAutophagy factors, then are efficiently incorporated into autophosome adaptors through binding with autophile adaptors.
- Type
- review
- Published
- 2015-10-01
- Cited by
- 96
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W2061633455
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29722385
Keywords
Mitophagy, Autophagy, Parkin, Autophagosome, Cell biology
References
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- 3D tomography reveals connections between the phagophore and endoplasmic reticulum
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- p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
- A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
Cited by
- Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
- The Regulation of Lipid Metabolism and Mitochondrial Quality Control in Health and Disease
- AMPK and autophagy in glucose/glycogen metabolism.
- Molecular responses of alveolar epithelial A549 cells to chronic exposure to titanium dioxide nanoparticles: A proteomic view.
- Cannabinoid-induced autophagy: Protective or death role?
- Autophagy in Acute Kidney Injury
- Sirt1 and the Mitochondria
- Digesting the Expanding Mechanisms of Autophagy.
- The receptor proteins: pivotal roles in selective autophagy.
- Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation*
- Interactions between Autophagy and Inhibitory Cytokines
- mito-QC illuminates mitophagy and mitochondrial architecture in vivo
- Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system
- c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.
- Skeletal Muscle Regeneration in the Mouse
- Methods for Mitochondria and Mitophagy Flux Analyses in Stem Cells of Resting and Regenerating Skeletal Muscle.
- Mitochondrial quality control by the Pink1/Parkin system
- Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility
- New methods for monitoring mitochondrial biogenesis and mitophagy in vitro and in vivo
- Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy
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