c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.
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Summary
The JNK-Rubicon axis enhanced lipoapoptosis, and caspase-9 inhibition and Rubicon had effects that were cytologically similar to hepatocyte ballooning, which might provide anti-fibrosis in the NASH liver.
- Type
- article
- Published
- 2016-07-28
- Cited by
- 17
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W2487313069
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23443669
Keywords
Gene knockdown, Hepatocyte, Apoptosis, Biology, Protein kinase A
References
- Apoptosis and Necrosis in the Liver
- Autophagy and human diseases
- A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches
- Palmitoleate attenuates palmitate-induced bim and PUMA up-regulation and hepatocyte lipoapoptosis
- A Hedgehog Survival Pathway in ‘Undead’ Lipotoxic Hepatocytes
- Hepatocellular Ballooning in NASH
- Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
- Glycogen Synthase Kinase-3 (GSK-3) Inhibition Attenuates Hepatocyte Lipoapoptosis
- Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
- JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis*
- Pathological features of fatty liver disease.
- Genetics, diagnostics and therapeutic advances in NAFLD
- CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis.
- Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis.
- Cisplatin-Induced Apoptosis Inhibits Autophagy, Which Acts as a Pro-Survival Mechanism in Human Melanoma Cells
- Lipoapoptosis: its mechanism and its diseases.
- Autophagy machinery in the context of mammalian mitophagy.
- Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
- From Mallory to Mallory-Denk bodies: what, how and why?
- Design and validation of a histological scoring system for nonalcoholic fatty liver disease
Cited by
- Evaluation of ballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liver disease
- Noninvasive diagnostic criteria for nonalcoholic steatohepatitis based on gene expression levels in peripheral blood mononuclear cells
- Response to the letter by Sumida et al. regarding our manuscript “Evaluation of ballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liver disease”
- In Vitro Production of Human Ballooned Hepatocytes in a Cell Sheet-based Three-dimensional Model
- Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice
- A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
- Acinetobacter baumannii Targets Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) for Invasion of Pneumocytes
- Acanthopanax senticosus Harms extract causes G0/G1 cell cycle arrest and autophagy via inhibition of Rubicon in human liver cancer cells
- High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
- Predictive value of cytokeratin-18 fragment levels for diagnosing steatohepatitis in patients with nonalcoholic fatty liver disease
- Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet.
- In vitro ballooned hepatocytes can be produced by primary human hepatocytes and hepatic stellate cell sheets
- Excess fructose enhances oleatic cytotoxicity via reactive oxygen species production and causes necroptosis in hepatocytes.
- Transcriptomic evaluation of N6-methyladenosine modification can be used to identify differentially gene and immune-related biological processes in TX mice with liver fibrosis
- Morinda officinalis iridoid glycosides alleviate methotrexate-induced liver injury in CIA rats by increasing liver autophagy and improving lipid metabolism homeostasis.
- Truncated thrombospondin-1 polypeptide alleviates non-alcoholic fatty liver disease induced by palmitic acid and high-fat diets.
- In Vitro Ballooned Hepatocytes Can Be Produced By Primary Human Hepatocytes and Hepatic Stellate Cell Sheets
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