ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy*
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Summary
It is demonstrated by using both cellular experiments and a de novo in vitro reconstituted reaction that FIP200 and ATG13 can enhance ULK1 kinase activity individually but both are required for maximal stimulation, indicating that the ULK 1·ATG13·FIP200 complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis.
- Type
- article
- Published
- 2009-05-01
- Cited by
- 1,502
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W1918384196
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11458658
Keywords
Autophagy-related protein 13, Autophagy, ULK1, Cell biology, PI3K/AKT/mTOR pathway
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Cited by
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- Primary resistance to ATP-competitive mTOR inhibitors for the treatment of solid tumors
- Autophagy in Pancreatic Cancer
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- Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills breast cancer cells by autophagy and delays growth of triple negative breast cancer in athymic mice
- Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway
- Systematic analysis of ATG13 domain requirements for autophagy induction
- Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound
- The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein Aggregate Formation, and Macroautophagy
- Investigating the role of reactive oxygen species in regulating autophagy.
- Autophagy in breast cancer and its implications for therapy.
- Autophagy in mammalian cells.
- Cell cycle regulation by the nutrient-sensing mammalian target of rapamycin (mTOR) pathway.
- Etude de la régulation de l’autophagie au cours de la différenciation des cellules de leucémie aiguë promyélocytaire : rôles dans la survie et la différenciation cellulaire
- MTORC1 SIGNALING IN MEMORY FORMATION AND DYSFUNCTION
- Membrane-remodeling by SNX18 in endosomal transport and autophagy
- ANALYSIS OF THE ROLE OF TWO AUTOPHAGY PATHWAY RELATED GENES, BECN1 AND TSC1, IN MURINE MAMMARY GLAND DEVELOPMENT AND DIFFERENTIATION
- Modulating autophagy: a strategy for cancer therapy
- Kinase and Hormone Receptor Signaling Networks in Cancer
- Crosstalk between mTORC1 and cAMP Signaling
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