ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy*

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Summary

It is demonstrated by using both cellular experiments and a de novo in vitro reconstituted reaction that FIP200 and ATG13 can enhance ULK1 kinase activity individually but both are required for maximal stimulation, indicating that the ULK 1·ATG13·FIP200 complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis.

Type
article
Published
2009-05-01
Cited by
1,502
References
33
Access
Open access

Keywords

Autophagy-related protein 13, Autophagy, ULK1, Cell biology, PI3K/AKT/mTOR pathway

References

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