p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*
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Summary
It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.
- Type
- article
- Published
- 2007-08-17
- Cited by
- 4,567
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2014918593
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1831672
Keywords
ATG8, Autophagy, Ubiquitin, Degradation (telecommunications), Cell biology
References
- p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.
- Increased expression of p62 in expanded polyglutamine‐expressing cells and its association with polyglutamine inclusions
- p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
- The crystal structure of microtubule‐associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8
- Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
- Aggresomes, inclusion bodies and protein aggregation.
- Solution Structure of Microtubule-associated Protein Light Chain 3 and Identification of Its Functional Subdomains*
- The role of autophagy during the early neonatal starvation period
- Towards a proteome-scale map of the human protein–protein interaction network
- The molecular machinery of autophagy: unanswered questions
- Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation
- Production and characterization of monoclonal antibodies specific to multi‐ubiquitin chains of polyubiquitinated proteins
- Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments
- Human Light Chain 3/MAP1LC3B Is Cleaved at Its Carboxyl-terminal Met121 to Expose Gly120 for Lipidation and Targeting to Autophagosomal Membranes*
- The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.
- Protein degradation and protection against misfolded or damaged proteins
- Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages.
- Loss of autophagy in the central nervous system causes neurodegeneration in mice
- Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes*
Cited by
- Regulation of the aging process by autophagy.
- Autophagy is involved in the elimination of intracellular inclusions, Mallory-Denk bodies, in hepatocytes
- Rôle du stress du réticulum endoplasmique et de l’autophagie dans la régulation des réponses immune et angiogénique activées par des stress ischémiques et inflammatoires dans l’épithélium rénal humain
- Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
- Molecular machinery of macroautophagy and its deregulation in diseases.
- Curvature of Double-Membrane Organelles Generated by Changes in Membrane Size and Composition
- Internalized gap junctions are degraded by autophagy
- p62/SQSTM1/A170: physiology and pathology.
- Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway
- [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.
- MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.
- The scaffold protein EPG-7 links cargo–receptor complexes with the autophagic assembly machinery
- Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro
- Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement.
- Selective Autophagy: talking with the UPS
- Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state.
- Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages
- mTOR-INDEPENDENT INDUCTION OF AUTOPHAGY IN TRABECULAR MESHWORK CELLS SUBJECTED TO BIAXIAL STRETCH
- 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
- Coordinated activation of AMP‐activated protein kinase, extracellular signal‐regulated kinase, and autophagy regulates phorbol myristate acetate‐induced differentiation of SH‐SY5Y neuroblastoma cells
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