Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.
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Summary
A model for selective autophagy formation in close proximity to cargo is proposed and found that UBLs can directly engage the autophagosome nucleation machinery.
- Type
- review
- Published
- 2014-01-23
- Cited by
- 963
- References
- 86
- Access
- Open access
- OpenAlex
- https://openalex.org/W2001045944
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13113971
Keywords
Autophagy, ATG8, Biology, Autophagosome, Cell biology
References
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- Selective autophagy mediated by autophagic adapter proteins
- Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes
- LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy
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- ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex
- A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
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- The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome
- Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
- Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation
- p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*
Cited by
- Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis
- Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons
- Late-stage inhibition of autophagy enhances calreticulin surface exposure
- Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation
- Diverse Functions of Autophagy in Liver Physiology and Liver Diseases
- Zinc Protoporphyrin Suppresses β-Catenin Protein Expression in Human Cancer Cells: The Potential Involvement of Lysosome-Mediated Degradation
- A study on the autophagy receptor p62/SQSTM1. Impact of ATF4 and 5´untranslated region of mRNA upon amino acid deprivation
- The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing*
- Reduced mitochondrial Ca2+ transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase
- Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis.
- Defects in Retinal Pigment Epithelial Cell Proteolysis and the Pathology Associated with Age-related Macular Degeneration
- Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS
- Receptor-bound targets of selective autophagy use a scaffold protein to activate the Atg1 kinase
- Autophagy at the crossroads of catabolism and anabolism
- Hypoxia signaling pathways: modulators of oxygen-related organelles
- Compromised autophagy and neurodegenerative diseases
- Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis
- The Legionella anti-autophagy effector RavZ targets the autophagosome via PI3P- and curvature-sensing motifs
- N-terminal Arginylation Targets Endoplasmic Reticulum Chaperone BiP to Autophagy Through p62 Binding
- Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity
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