PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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Summary
Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
- Type
- article
- Published
- 2010-01-30
- Cited by
- 2,807
- References
- 40
- OpenAlex
- https://openalex.org/W2034087770
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26096413
Keywords
Parkin, PINK1, Mitophagy, VDAC1, Autophagy
References
- Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation
- p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
- Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
- The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series
- Parkin protects against tyrosinase‐mediated dopamine neurotoxicity by suppressing stress‐activated protein kinase pathways
- Mitochondrial membrane permeabilization in cell death.
- Alpha-synuclein and neurodegenerative diseases
- The PINK1/Parkin pathway regulates mitochondrial morphology
- Diagnosis and treatment of Parkinson disease: molecules to medicine.
- The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins
- The kinase domain of mitochondrial PINK1 faces the cytoplasm
- Diverse Effects of Pathogenic Mutations of Parkin That Catalyze Multiple Monoubiquitylation in Vitro*
- p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*
- PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.
- Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
- Ubiquitin Recognition by the Ubiquitin-associated Domain of p62 Involves a Novel Conformational Switch*
- The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin*
- Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
- Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.
Cited by
- Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
- Autophagy Shapes Inflammation
- Molecular machinery of macroautophagy and its deregulation in diseases.
- The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim?
- Recovery of MERRF Fibroblasts and Cybrids Pathophysiology by Coenzyme Q10
- Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation*
- Cellular consequences of oxidative stress in riboflavin responsive multiple acyl-CoA dehydrogenation deficiency patient fibroblasts.
- Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage.
- Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase
- Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.
- Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1
- Carbon monoxide impairs mitochondria‐dependent endosomal maturation and antigen presentation in dendritic cells
- MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression*
- Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases.
- Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons
- Melatonin attenuates traumatic brain injury‐induced inflammation: a possible role for mitophagy
- AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics.
- VDAC in cancer.
- Lysosomal Biology in Cancer
- Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes
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- Commitment in the PINK1/Parkin mitophagy decision circuit
- Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
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