p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
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Summary
It is shown that Parkin‐catalyzed K63‐linked polyubiquitylation of depolarized mitochondria resulted in ubiquitylated mitochondria being transported along microtubules to cluster in the perinuclear region, which was interfered by pathogenic mutations of Parkin.
- Type
- article
- Published
- 2010-08-01
- Cited by
- 421
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1904531393
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15475985
Keywords
Parkin, PINK1, Biology, Mitochondrion, Ubiquitin
References
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- p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
- Does Impairment of the Ubiquitin-Proteasome System or the Autophagy-Lysosome Pathway Predispose Individuals to Neurodegenerative Disorders such as Parkinson's Disease?
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- Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
- Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA
- What is the role of protein aggregation in neurodegeneration?
- Genes to cells: edited by Jun-ichi Tomizawa, Blackwell Science Ltd. Institutional: £218.00 (Europe), £242.00 (Rest of World), US382.00 (USA and Canada). Individual: £65.00 (Europe), £72.00 (Rest of World), US114.00 (USA and Canada) ISSN 1356 9597
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
- Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics.
- Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies
- In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies.
- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
- Ubiquitin–proteasome system dysfunction in Parkinson’s disease: current evidence and controversies
- Control of mitochondrial transport and localization in neurons.
- Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
- Diverse Effects of Pathogenic Mutations of Parkin That Catalyze Multiple Monoubiquitylation in Vitro*
- p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*
- Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin
Cited by
- p62/SQSTM1/A170: physiology and pathology.
- Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation*
- Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.
- Role of glutathione s-transferase pi in neuronal protection under oxidative stress and proteasome inhibition relevance to Parkinson’s disease
- Mitochondrial Dynamics: The Intersection of Form and Function
- Oxygen-sensing and Mitochondrial Control of Cell Function
- Rôle de la dysfonction mitochondriale dans deux maladies neurodégénératives, la Maladie de Huntington et la Maladie de Parkinson
- Molecular Mechanisms of Mitochondrial Transport in Neurons
- Analysis of mitochondrial quality control using a Drosophila model of Parkinson’s disease
- The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
- Cell biology: Tagged tags engage disposal
- Regulation of mitophagy in ischemic brain injury
- Characterization of Mild Oxidative Stress Response in Human IMR-90 Fibroblasts by Subcellular Quantitative Proteomics
- Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2
- A Whole Genome RNAi Screen to Identify Novel Promoters of PINK1/Parkin-mediated Mitophagy
- Bioenergetics mechanism and autophagy in breast cancer stem cells
- Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?
- Cellular function and toxicity of the Parkinson’s disease-related genes α-synuclein and catp-6 in C. elegans
- Deubiquitinating enzymes regulate PARK2-mediated mitophagy
- Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy
Related papers
- Induction of PINK1/Parkin-Mediated Mitophagy.
- Deciphering the Molecular Signals of PINK1/Parkin Mitophagy.
- Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells.
- PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes
- Commitment in the PINK1/Parkin mitophagy decision circuit
- PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
- Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
- Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila