Epigenetic modifications and human disease
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Summary
A comprehensive understanding of epigenetic mechanisms, their interactions and alterations in health and disease, has become a priority in biomedical research.
- Type
- review
- Published
- 2010-10-01
- Cited by
- 2,769
- References
- 177
- OpenAlex
- https://openalex.org/W1985444222
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3346771
Keywords
Epigenetics, Epigenomics, DNA methylation, Biology, Computational biology
References
- Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
- A microRNA DNA methylation signature for human cancer metastasis
- Dnmt3L and the Establishment of Maternal Genomic Imprints
- Chromatin and the pluripotent ground state
- The SWI/SNF complex — chromatin and cancer
- Insulin Gene Expression Is Regulated by DNA Methylation
- Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
- The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells
- Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability.
- Epigenetic modifications in pluripotent and differentiated cells
- Elevated nuclear maspin expression is associated with microsatellite instability and high tumour grade in colorectal cancer
- Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1
- A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
- Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.
- Locking in on the human methylome
- Rethinking how DNA Methylation Patterns are Maintained
- Mecp2-Null Mice Provide New Neuronal Targets for Rett Syndrome
- Chromatin regulation by Brg1 underlies heart muscle development and disease
- H3K79 methylation profiles define murine and human MLL-AF4 leukemias
- Proteins that bind methylated DNA and human cancer: reading the wrong words
Cited by
- Biological signature of HER2-positive breast cancer
- Effects of DNA Methyltransferase- and Histone Deacetylase Inhibitors on ALK Positive Anaplastic Large Cell Lymphoma
- The sperm epigenome: implications for the embryo.
- Reduced Representation Bisulfite Sequencing of Human Neutrophils Reveals Widespread Inter-Individual Epigenetic Variation
- Bottom-up and middle-down proteomics have comparable accuracies in defining histone PTM relative abundance and stoichiometry
- Epigenetics Lights Up the Obesity Field
- Gene-environment interaction in chronic disease: a European Science Foundation Forward Look.
- Methylation status of NEUROG2 and NID2 improves the diagnosis of stage I NSCLC.
- Effects of deranged metabolism on epigenetic changes in cancer
- Overlapping DNA Methylation Dynamics in Mouse Intestinal Cell Differentiation and Early Stages of Malignant Progression
- Is this the right normalization? A diagnostic tool for ChIP-seq normalization
- Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma
- Short‐term calorie restriction ameliorates genomewide, age‐related alterations in DNA methylation
- Epigenetic regulation of hepatic stellate cell activation and liver fibrosis
- The Physiopathology of Cardiorenal Syndrome: A Review of the Potential Contributions of Inflammation
- Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.
- Blockade of receptors of advanced glycation end products ameliorates diabetic osteogenesis of adipose‐derived stem cells through DNA methylation and Wnt signalling pathway
- Replication-dependent histone isoforms: a new source of complexity in chromatin structure and function
- Tackling malignant melanoma epigenetically: histone lysine methylation
- Review: Epigenetic mechanisms in ocular disease
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