Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
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Summary
It is shown that human cells lacking DNA methyltransferase 1 (Dnmt1), but not Dnmt33b, have a loss of DNA methylation and an increase in the acetylation level of lysine 16 histone H4 at the rRNA genes.
- Type
- article
- Published
- 2007-03-13
- Cited by
- 148
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964232579
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:566489
Keywords
Biology, Fibrillarin, Nucleolus, DNA methylation, Molecular biology
References
- CpG methylation is maintained in human cancer cells lacking DNMT1
- To be or not to be in the nucleolus
- Emerging concepts of nucleolar assembly.
- Epigenetic silencing of RNA polymerase I transcription
- Human DNA Methyltransferase 1 Is Required for Maintenance of the Histone H3 Modification Pattern*
- Acetylation of TAFI68, a subunit of TIF‐IB/SL1, activates RNA polymerase I transcription
- Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity.
- Two different chromatin structures coexist in ribosomal RNA genes throughout the cell cycle.
- The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription
- A Kinetic Framework for a Mammalian RNA Polymerase in Vivo
- DNase I sensitivity of ribosomal RNA genes in chromatin and nucleolar dominance in wheat.
- The moving parts of the nucleolus
- Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects.
- Regulation of ubiquitin ligase dynamics by the nucleolus
- The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
- The silence of the ribosomal RNA genes
- Location of ribosomal DNA in the human chromosome complement.
- Role of DNA Methyltransferases in Regulation of Human Ribosomal RNA Gene Transcription*
- Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription.
- Nucleolar proteome dynamics
Cited by
- Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context
- Plant 45S rDNA Clusters Are Fragile Sites and Their Instability Is Associated with Epigenetic Alterations
- Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes.
- Methyllysine Reader Plant Homeodomain (PHD) Finger Protein 20-like 1 (PHF20L1) Antagonizes DNA (Cytosine-5) Methyltransferase 1 (DNMT1) Proteasomal Degradation*
- MPP8 and SIRT1 crosstalk in E‐cadherin gene silencing and epithelial–mesenchymal transition
- DNA Methylation: An Epigenetic mechanism in oral squamous cell carcinoma
- MicroRNA-137 promoter methylation as an etiologic and prognostic biomarker for squamous cell carcinoma of the head and neck
- Nucleolus: the ribosome factory.
- DNA methylation in chromatin - complexes and mechanisms
- Nucleolar epigenomics by dynamic molecular combing and nucleolar matrix analysis
- Epigenetics in Biology and Medicine
- The epigenetics of aging and neurodegeneration
- Hypermethylation in gastric cancer.
- DNA Methylation, Cellular Stress Response and Expression of Inner Nuclear Membrane Proteins
- Chromatin Modifications during Repair of Environmental Exposure-Induced DNA Damage: A Potential Mechanism for Stable Epigenetic Alterations
- Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
- Sirtuins and p53.
- Analysis of the DNA damage response in living cells
- Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
- Identification and characterisation of Mybbp1a as a regulator of rRNA synthesis
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