A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
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Summary
It is proposed that bivalent domains silence developmental genes in ES cells while keeping them poised for activation, highlighting the importance of DNA sequence in defining the initial epigenetic landscape and suggesting a novel chromatin-based mechanism for maintaining pluripotency.
- Type
- article
- Published
- 2006-04-21
- Cited by
- 5,506
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1968931043
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9993008
Keywords
Biology, Chromatin, Bivalent (engine), Bivalent chromatin, Epigenetics
References
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- Genomic maps and comparative analysis of histone modifications in human and mouse.
- Human but Not Yeast CHD1 Binds Directly and Selectively to Histone H3 Methylated at Lysine 4 via Its Tandem Chromodomains*
- Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
- Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell
- Expression profiling and identification of novel genes involved in myogenic differentiation
- Histone variants, nucleosome assembly and epigenetic inheritance.
- Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin.
- Generation of mice from wild-type and targeted ES cells by nuclear cloning
- Mapping of genetic and epigenetic regulatory networks using microarrays
- Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro.
- Study of stem cell function using microarray experiments
- Comprehensive analysis of CpG islands in human chromosomes 21 and 22
Cited by
- JAK2V617F-positive Myeloproliferative Neoplasms : KI mouse models, Interferon-α therapy and clonal architecture
- Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation.
- The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes
- Phenotypic Plasticity and Epigenetics In The Honeybee Ovary
- Sequential chromatin immunoprecipitation assay and analysis.
- MicroChIP: chromatin immunoprecipitation for small cell numbers.
- ESCs keep their options open
- Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
- The many faces of ubiquitinated histone H2A: insights from the DUBs
- Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
- Inferring causal relationships among different histone modifications and gene expression.
- Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
- Differential remodeling of mono‐ and trimethylated H3K27 during porcine embryo development
- A timing mechanism for stem cell maintenance and differentiation in the Arabidopsis floral meristem.
- Mechanisms of Polycomb gene silencing: knowns and unknowns
- Discovery and Annotation of Functional Chromatin Signatures in the Human Genome
- Developmental gene regulation in the era of genomics.
- Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency
- Coordinated histone modifications are associated with gene expression variation within and between species.
- Integrating post‐transcriptional regulation into the embryonic stem cell gene regulatory network
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