Insulin Gene Expression Is Regulated by DNA Methylation
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Summary
The findings suggest that insulin promoter CpG demethylation may play a crucial role in beta cell maturation and tissue-specific insulin gene expression.
- Type
- article
- Published
- 2009-09-09
- Cited by
- 315
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W1963929665
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17124794
Keywords
DNA methylation, Biology, Promoter, Epigenetics of physical exercise, Molecular biology
References
- Nutrient regulation of insulin gene expression
- Protein production by auto-induction in high density shaking cultures.
- Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.
- Environmental epigenomics and disease susceptibility
- Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA.
- Characterization of the two nonallelic genes encoding mouse preproinsulin
- Identification and Purification of Functional Human β-cells by a New Specific Zinc-fluorescent Probe
- Glucose-induced Translational Control of Proinsulin Biosynthesis Is Proportional to Preproinsulin mRNA Levels in Islet β-Cells but Not Regulated via a Positive Feedback of Secreted Insulin*
- Generation of Human Islets Through Expansion and Differentiation of Non-islet Pancreatic Cells Discarded (Pancreatic Discard) After Islet Isolation
- Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
- DNA methylation and human disease
- Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
- ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence.
- Regulation of insulin receptor function
- Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.
- Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene.
- Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.
- Role of beta-cells in type 1 diabetes pathogenesis.
- Regulation of insulin gene transcription
- Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?
Cited by
- Epigenetics Lights Up the Obesity Field
- Global DNA Methylation Is Associated With Insulin Resistance
- Development of a Quantitative Methylation-Specific Polymerase Chain Reaction Method for Monitoring Beta Cell Death in Type 1 Diabetes
- DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes.
- XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT
- Differentiation of pancreatic and hepatic cell types
- Análise da expressão gênica no tumor ósseo de células gigantes
- Laminin-1 mediates epigenetic control of the epithelial cadherin for breast cancer cells in three-dimensional culture
- Early life origins of metabolic disease: Developmental programming of hypothalamic pathways controlling energy homeostasis.
- Activin receptor-like kinase and the insulin gene.
- The Role of Epigenetics in Arterial Calcification
- Methylation of human papillomavirus DNA : biological significance and clinical utility
- Genetic and epigenetic mechanisms in primary hyperparathyroidism
- Methylation-dependent and independent regulatory regions in the Na,K-ATPase alpha4 gene (Atp1a4) may impact its testis-specific expression
- The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes
- Differences in promoter DNA methylation and mRNA expression of individual alleles of the HLA class II DQA1 gene.
- Epigenetic signature in persons with Down Syndrome
- Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?
- Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes.
- Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes
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