Elevated nuclear maspin expression is associated with microsatellite instability and high tumour grade in colorectal cancer
Explore this paper's citation graph
Summary
Significant upregulation of maspin expression was found in MSI‐H tumours compared to both MSS/MSI‐L tumours and matched benign colonic mucosa, which may be useful for diagnosis and treatment strategies.
- Type
- article
- Published
- 2005-04-01
- Cited by
- 88
- References
- 48
- OpenAlex
- https://openalex.org/W1967029216
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40849007
Keywords
Maspin, Microsatellite instability, Colorectal cancer, Cancer research, Metastasis
References
- Modeling human breast cancer metastasis in mice: maspin as a paradigm.
- Expression of Maspin in Colon Cancers: Its Relationship with p53 Expression and Microvessel Density
- mMaspin: The Mouse Homolog of a Human Tumor Suppressor Gene Inhibits Mammary Tumor Invasion and Motility
- Maspin is an angiogenesis inhibitor
- Genetic instabilities in human cancers
- Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression.
- Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2.
- Chromosome 18 deletions are common events in classical midgut carcinoid tumors
- Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells.
- Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis
- Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas.
- A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia.
- A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.
- Identification of a chromosome 18q gene that is altered in colorectal cancers.
- Maspin – the most commonly-expressed gene of the 18q21.3 serpin cluster in lung cancer – is strongly expressed in preneoplastic bronchial lesions
- Expression of maspin predicts poor prognosis in breast‐cancer patients
- The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.
- Gene expression profiling of colorectal cancer and metastases divides tumours according to their clinicopathological stage
- Expression and regulation of tumor suppressor gene maspin in breast cancer.
- Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.
Cited by
- Immunohistochemical Features of 3,3′,4,4′-Tetrachloroazobenzene-Induced Rat Gingival Lesions
- Role of epigenetics in inflammation-associated diseases.
- BRCA1 185delAG mutant protein, BRAt, amplifies caspase-mediated apoptosis and maspin expression in ovarian cells
- Maspin expression in the invasive margin of primary melanomas may reflect an aggressive tumor phenotype
- The Emerging Role of the Thrombin Receptor (PAR-1) in Melanoma Metastasis - a Possible Therapeutic Target
- Cell culture models and novel gene therapeutic strategies for colorectal cancer
- Serpin B5 is a CEA‐interacting biomarker for colorectal cancer
- The maspin expression in canine mammary tumors: an immunohistochemical and molecular study
- Maspin (SERPINB5) Is an Obligate Intracellular Serpin*
- SERPINB5 and AKAP12 -- Expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma
- Nuclear maspin expression as a predictive marker for fluorouracil treatment response in colon cancer
- Nuclear Maspin expression is associated with response to adjuvant 5‐fluorouracil based chemotherapy in patients with stage III colon cancer
- Epigenetic modifications and human disease
- Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node‐positive colonic cancer
- Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma.
- Basic Mechanics of DNA Methylation and the Unique Landscape of the DNA Methylome in Metal-Induced Carcinogenesis
- Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer.
- DNA hypomethylation and human diseases.
- Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression
- DNA methylation pattern of the SLC25A43 gene in breast cancer
Related papers
- Prognostic significance of the maspin tumor suppressor gene in pulmonary adenocarcinoma
- Prognostic significance of tumor suppressor gene maspin in pulmonary adenocarcinoma
- Prognostic significance of tumor suppressor gene maspin in pulmonary adenocarcinoma.
- MASPIN tumour-suppressing activity in head and neck squamous cell carcinoma: Emerging evidence and therapeutic perspectives
- The expression of Maspin in mucoepidermoid carcinoma of salivary gland and its clinical significance
- Cytoplasmic-only Expression of Maspin Predicts Unfavorable Prognosis in Patients With Pancreatic Ductal Adenocarcinoma
- Maspin and it’s evolving role in tumor progression in systemic malignancies
- Maspin gene expression is a significant prognostic factor in resected non-small cell lung cancer (NSCLC). Maspin in NSCLC.