Dnmt3L and the Establishment of Maternal Genomic Imprints

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Summary

Bisulfite genomic sequencing of DNA from oocytes and embryos showed that removal of Dnmt3L prevented methylation of sequences that are normally maternally methylated, and the defect was specific to imprinted regions, and global genome methylation levels were not affected.

Type
article
Published
2001-11-22
Cited by
1,425
References
36

Keywords

Genomic imprinting, Biology, Genetics, DNA methylation, Methyltransferase

References

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