Dnmt3L and the Establishment of Maternal Genomic Imprints
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Summary
Bisulfite genomic sequencing of DNA from oocytes and embryos showed that removal of Dnmt3L prevented methylation of sequences that are normally maternally methylated, and the defect was specific to imprinted regions, and global genome methylation levels were not affected.
- Type
- article
- Published
- 2001-11-22
- Cited by
- 1,425
- References
- 36
- OpenAlex
- https://openalex.org/W1673514954
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14857659
Keywords
Genomic imprinting, Biology, Genetics, DNA methylation, Methyltransferase
References
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- Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
- Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
- High sensitivity mapping of methylated cytosines.
- Parental imprinting of autosomal mammalian genes.
- Parental-origin-specific epigenetic modification of the mouse H19 gene
- The Sins of the Fathers and Mothers Genomic Imprinting in Mammalian Development
- Completion of mouse embryogenesis requires both the maternal and paternal genomes.
- Epigenetic Instability in ES Cells and Cloned Mice
- The paternal methylation imprint of the mouse H19 locus is acquired in the gonocyte stage during foetal testis development
- Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal.
- Death before birth: clues from gene knockouts and mutations.
- Role of paternal and maternal genomes in mouse development
- A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome.
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
- Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
- Hhal methyltransferase flips its target base out of the DNA helix
- Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.
- Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.
Cited by
- Establishment and maintenance of DNA methylation patterns in mammals.
- The role of nuclear position and locus conformation in regulating V(D)J recombination of the Tcrb locus
- DNA methylation analysis of germ cells by using bisulfite-based sequencing methods.
- Epigenetic reprogramming in mammalian nuclear transfer.
- Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?
- Genomic imprinting and methylation: epigenetic canalization and conflict.
- Genomic Imprinting and Assisted Reproductive Technology: Connections and Potential Risks
- Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1
- Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor
- Transient relaxation of transposon silencing at the onset of mammalian meiosis
- Epigenetic Drug Discovery
- SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice
- Pre-implantation alcohol exposure and developmental programming of FASD: an epigenetic perspective.
- Etude du réseau transcriptionnel du gène Xist, acteur principal de l'inactivation du chromosome X
- An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
- DNA methylation and cancer.
- Methods and Mechanisms of DNA methylation in Development and Disease
- An Improved Antibody-based Method to Detect Whole Genome Cytosine Methylation in Mouse Embryonic Fibroblasts
- Effects of chronic exercise on global DNA methylation and epigenetic factors in sperm and testes of mice.
- Réorganisation de l'épigénome au cours de la spermiogénèse
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