c-Myc-regulated microRNAs modulate E2F1 expression
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Summary
A mechanism through which c-Myc simultaneously activates E2F1 transcription and limits its translation, allowing a tightly controlled proliferative signal is revealed.
- Type
- article
- Published
- 2005-06-09
- Cited by
- 3,048
- References
- 29
- OpenAlex
- https://openalex.org/W1977372263
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4424010
Keywords
microRNA, E2F1, Biology, Transcription factor, Cell biology
References
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- Characterization of Nucleophosmin (B23) as a Myc Target by Scanning Chromatin Immunoprecipitation*
- Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
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- The functions of animal microRNAs
- E2F target genes: unraveling the biology.
- Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.
- Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
- Identification of c-myc responsive genes using rat cDNA microarray.
- Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.
- Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.
- A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
- An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets
- Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regions.
Cited by
- Enhancing CHO cell productivity through the stable depletion of microRNA-23
- Short RNAs repress translation after initiation in mammalian cells.
- CRSD: a comprehensive web server for composite regulatory signature discovery
- The MAX-interacting transcription factor network.
- MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
- Peroxisome Proliferator-Activated Receptor α Regulates a MicroRNA-Mediated Signaling Cascade Responsible for Hepatocellular Proliferation
- miRNAs in cancer: approaches, aetiology, diagnostics and therapy.
- The H19 Non-Coding RNA Is Essential for Human Tumor Growth
- Translational Medicine: microRNAs: a new emerging class of players for disease diagnostics and gene therapy
- p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
- Repressing the repressor: A new mode of MYC action in lymphomagenesis
- Tissue and Process Specific microRNA–mRNA Co-Expression in Mammalian Development and Malignancy
- MicroRNAs in breast cancer
- Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis
- Myc - miR-17~92 axis blunts TGFβ signaling and production of multiple TGFβ-dependent anti-angiogenic factors
- Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency
- Targeting MYC-Regulated miRNAs to Combat Cancer.
- MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2
- RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1-Induced Proliferation
- MicroRNAs and the Warburg Effect: new players in an old arena.
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