A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
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Summary
An unbiased genome-wide location-analysis approach is used to examine the genomic binding sites of c-Myc in Burkitt's lymphoma cells to suggest a general role for overexpressed c- myc in global transcriptional regulation in some cancer cells and point toward molecular mechanisms for c-myc function in malignant transformation.
- Type
- article
- Published
- 2003-06-13
- Cited by
- 587
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W2120006551
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:77747
Keywords
Promoter, Biology, Transcription factor, Gene, Transcription (linguistics)
References
- Definition of regions in human c-myc that are involved in transformation and nuclear localization
- The Myc/Max/Mad network and the transcriptional control of cell behavior.
- Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.
- c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability.
- The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
- c-MYC: more than just a matter of life and death
- Tumorigenicity of human hematopoietic cell lines in athymic nude mice
- The ornithine decarboxylase gene is a transcriptional target of c-Myc.
- Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development.
- Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation
- Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae: High-Resolution Mapping of Replication Origins
- Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
- Sequence-specific DNA binding by the c-Myc protein.
- The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation
- Reversible tumorigenesis by MYC in hematopoietic lineages.
- The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1
- Large-scale analysis of the human and mouse transcriptomes
- Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
- Translocations involving c-myc and c-myc function
- TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
Cited by
- CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome
- Protein Interaction Networks
- Essential Role of p400/mDomino Chromatin-remodeling ATPase in Bone Marrow Hematopoiesis and Cell-cycle Progression*
- Transcriptional control of DNA replication licensing by Myc
- Identification of Transcriptional Regulators Using Binding Site Enrichment Analysis
- Einfluss des Tyrosinkinase-Inhibitors Imatinib auf das ErbB3-Receptor Binding Protein1 (Ebp1) in der CML
- Integrating gene expression signals with bounded collection grammars
- Myc target transcriptomes.
- Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
- The role of the proline rich homeodomain in the regulation of proliferation, survival and migration of breast cells
- Insights into MYC biology through investigation of synthetic lethal interactions with MYC deregulation
- An investigation of the regulation of BLIMP1 by the epstein-barr virus in B cells
- Investigating the anti-apoptotic role of EBV in endemic Burkitt lymphona
- Epstein-Barr virus genome loss from Endemic Burkitt lymphoma and its effect on cell phenotype
- The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation
- Myc-mediated control of gene transcription in cancer cells
- The Circadian Clock in Cancer Development and Therapy
- Function and regulation of myc-family bHLHZip transcription factors during the animal and plant cell cycle
- Pluripotency and genetic stability of human pluripotent stem cells
- MYCN Affects DNA Repair Activity in Neuroblastoma
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