Characterization of Nucleophosmin (B23) as a Myc Target by Scanning Chromatin Immunoprecipitation*
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Summary
This work focused on nucleophosmin, also known as B23, which was identified as a candidate Myc-responsive gene from a subtractive hybridization screen, and found that sequences in intron 1, and not 5′ sequences in the proximal promoter, are bound by c-Myc in vivo.
- Type
- article
- Published
- 2001-12-21
- Cited by
- 125
- References
- 24
- Access
- Open access
- OpenAlex
- https://openalex.org/W1554666790
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21479186
Keywords
Chromatin immunoprecipitation, Transcription factor, ChIP-on-chip, Biology, Transcription coregulator
References
- Definition of regions in human c-myc that are involved in transformation and nuclear localization
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- c-Myc target gene specificity is determined by a post-DNAbinding mechanism.
- Drosophila myc regulates cellular growth during development.
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- A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins.
- c-Myc enhances protein synthesis and cell size during B lymphocyte development.
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- Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
- N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
- Mapping the Functional Domains of Nucleolar Protein B23*
- The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody
- Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion.
- Direct recruitment of N‐myc to target gene promoters
- Identification of c-myc responsive genes using rat cDNA microarray.
- In vivo interaction of nucleophosmin/B23 and protein C23 during cell cycle progression in HeLa cells.
- Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis.
- Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius
Cited by
- Nucleophosmin acts as a novel AP2α‐binding transcriptional corepressor during cell differentiation
- Oncogenic role of nucleophosmin/B23.
- Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1
- Myc target transcriptomes.
- Entwicklung und Anwendung neuer Analyseverfahren zur Differenzierung muriner embryonaler Stammzellen
- Les gènes TWIST : cibles transcriptionnelles des gènes MYC dans le neuroblastome
- Drosophila Low Temperature Viability Protein 1 (LTV1) Is Required for Ribosome Biogenesis and Cell Growth Downstream of Drosophila Myc (dMyc)*
- Role of p14ARF-HDM2-p53 axis in SOX6-mediated tumor suppression
- From cell surface to nucleus:Unraveling cancer metastasis and the role of nucleophosmin in breast cancer
- To reactivate or not to reactivate : Control of KSHV lytic replication is essential for apoptosis in response to p53 restoration
- Etude des mécanismes moléculaires par lesquels les méthyltransférases de l'ADN établissent les profils de méthylation
- Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters
- Genome-wide gain-of-function screen identifies novel regulators of pluripotency
- c-Myc-regulated microRNAs modulate E2F1 expression
- Myc represses transcription through recruitment of DNA methyltransferase corepressor
- NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling
- Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
- Finding Primary Targets of Transcriptional Regulators
- Targeting the nucleolus for cancer intervention.
- HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks
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