Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.
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Summary
It is demonstrated that, in post-log phase cells under respiratory conditions, a substantial fraction of mitochondria are exclusively sequestered as cargoes and transported to the vacuole, a lytic compartment in yeast, in an autophagy-dependent manner and suggested that Atg32, a mitochondria-anchored protein essential for mitophagy that is induced during respiratory growth, interacts with Atg8 and Atg11, autophatic proteins critical for recognition of cargo receptors.
- Type
- article
- Published
- 2009-07-21
- Cited by
- 853
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W1969971911
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38371068
Keywords
Mitophagy, Autophagy, Mitochondrion, Biology, Cell biology
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- Effect of mitochondrial stress on systemic metabolism
- Mitochondrial autophagy in cardiomyopathy
- Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy
- Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain.
- Lithocholic Acid and Macromitophagy Regulate the Dynamics of Lipid Metabolism and Storage to Modulate Chronological Aging in Saccharomyces cerevisiae
- Assays for autophagy II: Mitochondrial autophagy.
- Biological pathways involved in the development of inflammatory bowel disease
- Characterization of FHL2 expression and function in breast cancer cell lines
- Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis
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- Le peptide NFL-TBS.40-63 issu des neurofilaments : agent thérapeutique et outil de ciblage des cellules de glioblastome et des cellules souches neurales.
- Mitochondrial degradation and energy metabolism.
- Biogenesis of endosome-derived transport carriers
- Aging Research in Yeast
- INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
- Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
- Mechanisms Underlying the Essential Role of Mitochondria in Chronological Aging of the Yeast Saccharomyces cerevisiae
- Mitophagy and deubiquitination in yeast – the power of synthetic quantitative array technology
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