Lithocholic Acid and Macromitophagy Regulate the Dynamics of Lipid Metabolism and Storage to Modulate Chronological Aging in Saccharomyces cerevisiae

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Summary

It was found that deletion of Atg32p shortened yeast chronological lifespan (CLS) under caloric restriction growth conditions and abrogated the life-extending capabilities of lithocholic acid (LCA) – a bile acid that extends CLS even under caloric restrictions conditions and showed that mitophagy as well as lipid storage pathways and peroxisomal beta-oxidation of free fatty acids are protective processes against POA induced programmed cell death.

Type
dissertation
Published
2014-05-22
Cited by
0
References
191
Access
Open access

Keywords

Biology, Saccharomyces cerevisiae, Mitochondrion, Population, Yeast

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