Lithocholic Acid and Macromitophagy Regulate the Dynamics of Lipid Metabolism and Storage to Modulate Chronological Aging in Saccharomyces cerevisiae
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Summary
It was found that deletion of Atg32p shortened yeast chronological lifespan (CLS) under caloric restriction growth conditions and abrogated the life-extending capabilities of lithocholic acid (LCA) – a bile acid that extends CLS even under caloric restrictions conditions and showed that mitophagy as well as lipid storage pathways and peroxisomal beta-oxidation of free fatty acids are protective processes against POA induced programmed cell death.
- Type
- dissertation
- Published
- 2014-05-22
- Cited by
- 0
- References
- 191
- Access
- Open access
- OpenAlex
- https://openalex.org/W39873056
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81303838
Keywords
Biology, Saccharomyces cerevisiae, Mitochondrion, Population, Yeast
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