Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

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Summary

It is shown that the protein kinase activity of Apg1 is enhanced by starvation or rapamycin treatment, and it is found that Apg13, which binds to and activates ApG1, is hyperphosphorylated in a Tor-dependent manner, reducing its affinity to Apg 1.

Type
article
Published
2000-09-18
Cited by
1,227
References
27
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Open access

Keywords

Autophagy, Vacuole, Biology, Cell biology, Autophagy-related protein 13

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