Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex
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Summary
It is shown that the protein kinase activity of Apg1 is enhanced by starvation or rapamycin treatment, and it is found that Apg13, which binds to and activates ApG1, is hyperphosphorylated in a Tor-dependent manner, reducing its affinity to Apg 1.
- Type
- article
- Published
- 2000-09-18
- Cited by
- 1,227
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964257510
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:802977
Keywords
Autophagy, Vacuole, Biology, Cell biology, Autophagy-related protein 13
References
- Methods in yeast genetics
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- Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
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- Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae.
- Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways
- Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.
- Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast*
- Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae.
- The TOR signaling cascade regulates gene expression in response to nutrients.
- The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.
- TOR signalling and control of cell growth.
- Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.
- Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.
Cited by
- Protein targeting to endosomes and phagosomes via FYVE and PX domains.
- Autophagy: cerebral home cooking.
- Amino acid regulation of autophagosome formation.
- Atg17 regulates the magnitude of the autophagic response.
- The significance of autophagy in cancer
- TOR signaling in growth and metabolism.
- The Regulation of Autophagy in Eukaryotic Cells: Do All Roads Pass through Atg1?
- How Saccharomyces responds to nutrients.
- Autophagy in aging and in neurodegenerative disorders
- Direct activation of mTOR in B lymphocytes confers impairment in B‐cell maturation andloss of marginal zone B cells
- Autophagy vitalizes the pathogenicity of pathogenic fungi
- Studies of the Molecular Mechanism and Signaling Regulation of Autophagy in Saccharomyces Cerevisiae.
- mTOR Activation Promotes Plasma Cell Differentiation and Bypasses XBP-1 for Immunoglobulin Secretion
- Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills breast cancer cells by autophagy and delays growth of triple negative breast cancer in athymic mice
- RETRACTED: The Autophagic Process Occurs in Human Bone Metastasis and Implicates Molecular Mechanisms Differently Affected by Rab5a in the Early and Late Stages
- TOR: the first 10 years.
- Chloroplast signaling and quality control.
- Mecanismes de toxicitat de la dopamina en cèl·lules de neuroblastoma humà SH-SY5Y
- Characterization of ENTH domain proteins and their interaction with SNAREs in S.cerevisiae
- The Role of Autophagy in Drosophila Metamorphosis
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