Mechanisms Underlying the Essential Role of Mitochondria in Chronological Aging of the Yeast Saccharomyces cerevisiae
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Summary
Evidence is provided that mitophagy, a selective autophagic degradation of aged and dysfunctional mitochondria, is a longevity assurance process that in chronologically aging yeast underlies the synergistic beneficial effects of CR and LCA on lifespan.
- Type
- dissertation
- Published
- 2015-02-01
- Cited by
- 0
- References
- 428
- Access
- Open access
- OpenAlex
- https://openalex.org/W909813120
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:82092126
Keywords
Mitochondrion, Saccharomyces cerevisiae, Yeast, Biology, Cell biology
References
- Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes.
- Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density
- Peroxule extension over ER-defined paths constitutes a rapid subcellular response to hydroxyl stress.
- Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation.
- Mitochondria as a pharmacological target: Magnum overview
- Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity
- 17 Molecular Mechanisms of Aging: Insights from Budding Yeast
- Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity.
- Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis
- Measurement of Mitochondrial Oxygen Consumption Using a Clark Electrode
- The retrograde response retrograde response and other pathways of interorganelle communication interorganelle communication in yeast replicative aging.
- Yeast Intermediary Metabolism
- Oxidative stresses and ageing.
- Guide to yeast genetics : functional genomics, proteomics, and other systems analysis
- Higher Respiratory Activity Decreases Mitochondrial Reactive Oxygen Release and Increases Life Span in Saccharomyces cerevisiae*
- Small-Molecule Allosteric Activators of Sirtuins
- Chronological Aging in Saccharomyces cerevisiae
- Genome-wide analysis of yeast aging.
- Spatiotemporal dynamics of the ER-derived peroxisomal endomembrane system.
- Searching Sequence Databases Over the Internet: Protein Identification Using MS‐Tag
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