The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

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Summary

Based on Apg protein localization, a novel structure that functions in autophagosome formation is identified and it is revealed that the formation of both a phosphatidylethanolamine‐conjugated Aut7p and an Apg12p–Apg5p conjugate is essential for the localization of Aut 7p to the pre‐autophagosomal structure.

Type
article
Published
2001-11-01
Cited by
1,064
References
45
Access
Open access

Keywords

Biology, Autophagosome, Autophagy, Cell biology, Phosphatidylinositol

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