The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
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Summary
Based on Apg protein localization, a novel structure that functions in autophagosome formation is identified and it is revealed that the formation of both a phosphatidylethanolamine‐conjugated Aut7p and an Apg12p–Apg5p conjugate is essential for the localization of Aut 7p to the pre‐autophagosomal structure.
- Type
- article
- Published
- 2001-11-01
- Cited by
- 1,064
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W1981358316
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40730978
Keywords
Biology, Autophagosome, Autophagy, Cell biology, Phosphatidylinositol
References
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- Genetic regulation of autophagic cell death in Drosophila melanogester
- An Overview of the Molecular Mechanism of Autophagy
- Approaches to the study of Atg8-mediated membrane dynamics in vitro.
- The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein Aggregate Formation, and Macroautophagy
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