Phases of Aβ-deposition in the human brain and its relevance for the development of AD
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Summary
Aβ-deposition in the entire brain follows a distinct sequence in which the regions are hierarchically involved and expands anterogradely into regions that receive neuronal projections from regions already exhibiting Aβ.
- Type
- article
- Published
- 2002-06-25
- Cited by
- 3,313
- References
- 49
- OpenAlex
- https://openalex.org/W1967823816
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41133337
Keywords
Brainstem, Pathology, Neocortex, Forebrain, Neuroscience
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- Functional Characterization of the Presenilin Homologue SPE-4
- GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide
- Staging of the cognitive decline in Alzheimer's disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's disease
- A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis
- Degree of abnormality is associated with rate of change in measures of beta-amyloid, glucose metabolism and cognition in an autopsy-verified Alzheimer’s disease case
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- Frontotemporal lobar degeneration due to P301L tau mutation showing apathy and severe frontal atrophy but lacking other behavioral changes: A case report and literature review
- Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease.
- The Role of Immunosenescence in Neurodegenerative Diseases
- In Vivo Characterization and Quantification of Neurofibrillary Tau PET Radioligand 18F-MK-6240 in Humans from Alzheimer Disease Dementia to Young Controls
- A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities
- A nonhuman primate model of early Alzheimer’s disease pathologic change: Implications for disease pathogenesis
- Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders
- Sleep–wake regulation and the hallmarks of the pathogenesis of Alzheimer’s disease
- Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation
- Saccades in Alzheimer’s disease: an MRI study.
- Human subiculo-fornico-mamillary system in Alzheimer’s disease: Tau seeding by the pillar of the fornix
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