Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis.
Explore this paper's citation graph
Summary
The results suggest that within the hippocampal/parahippocampal region there is a progressive stereotypic deposition of Abeta, and the variable severity of AbETA deposition within age groups suggests that other factors, besides DS, may be contributing to the timing and severity ofAbeta deposition.
- Type
- article
- Published
- 1998-04-01
- Cited by
- 222
- References
- 28
- OpenAlex
- https://openalex.org/W1994573232
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7253215
Keywords
Subiculum, Parahippocampal gyrus, Hippocampus, Pathology, Hippocampal formation
References
- The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.
- Antigenic profile of plaques and neurofibrillary tangles in the amygdala in Down's syndrome: a comparison with Alzheimer's disease.
- Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
- Mental Retardation: A Review of Research
- Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease
- Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease.
- Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital.
- Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
- Gender differences in the phenotypic expression of Alzheimer's disease in Down's syndrome (Trisomy 21)
- Presenile dementia and Alzheimer's disease in mongolism.
- Manual of histologic staining methods of the Armed forces institute of pathology
- The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimer's Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution
- Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
- Early senile dementia in mongoloid idiocy.
- Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome
- Histopathologische Untersuchungen über Entstehung und Wesen der senilen Plaques
- Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.
- Kunitz Protease Inhibitor‐Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease
- Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.
- The pathological association between Down syndrome and Alzheimer disease.
Cited by
- Exploring Alzheimer Molecular Pathology in Down's Syndrome Cerebrospinal Fluid
- Postmortale Diagnosestellung bei Morbus Alzheimer
- Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?
- Neuropathology of Alzheimer's disease: a critical update.
- Possible Compensatory Events in Adult Down Syndrome Brain Prior to the Development of Alzheimer Disease Neuropathology: Targets for Nonpharmacological Intervention
- Alzheimer's Disease in Adults with Down Syndrome.
- Assessing cognitive improvement in people with Down syndrome: important considerations for drug-efficacy trials.
- Neuroinflammation in Alzheimer's disease and Down syndrome
- Improvements in manual dexterity relate to improvements in cognitive planning after assisted cycling therapy (ACT) in adolescents with down syndrome.
- Expression profile analysis of vulnerable CA1 pyramidal neurons in young-middle aged Ts65Dn mice
- Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome
- Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-A system: insights for transition to Alzheimer Disease
- Patterns of aging in adults with intellectual disabilities
- Volumetric Analysis of Brain MRI for Alzheimer’s Disease
- COGNICIÓN Y LENGUAJE EN NIÑOS CRI-DU-CHAT Y DOWN. AVANCES DE UN ESTUDIO COMPARATIVO
- Apathy, genetics, and functional status in persons with Alzheimer Disease
- Serum MHPG Strongly Predicts Conversion to Alzheimer's Disease in Behaviorally Characterized Subjects with Down Syndrome
- A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
- Neurological phenotypes for Down syndrome across the life span
- Postnatal Development of the Hippocampus in the Rhesus Macaque (Macaca mulatta): A Longitudinal Magnetic Resonance Imaging Study
Related papers
- Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophrenia
- MRI findings in medial temporal lobe structures in schizophrenia.
- Duration of neurofibrillary changes in the hippocampal pyramidal neurons.
- Hippocampal pathology in diffuse Lewy body disease using ubiquitin immunohistochemistry.
- Non-haem iron histochemistry of the normal and Alzheimer's disease hippocampus.
- Alzheimer-type of pathological changes in Chinese.
- Tau association with aggresomes
- Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques.
- A volumetric MRI study of the hippocampus and the parahippocampal region after unilateral medial temporal lobe resection.