Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.

Keywords

Presenilin, Gliosis, Genetically modified mouse, Glial fibrillary acidic protein, Transgene

References

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• Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1Karen Duff, Chris Eckman, Cindy Zehr — 1996
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• Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.David Borchelt, Tamara Ratovitski, Judy van Lare — 1997
• Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.Takaomi C. Saido, Takeshi Iwatsubo, D.M.A. Mann — 1995
• The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.Joseph T. Jarrett, Elizabeth P. Berger, Peter T. Lansbury — 1993
• Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesLeigh A. Holcomb, Marcia N. Gordon, Eileen McGowan — 1998
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• The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry.Rong Wang, David Sweeney, Sam Gandy — 1996
• Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In VivoDavid Borchelt, Gopal Thinakaran, Christopher B. Eckman — 1996
• Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseDonalyn Scheuner, Christopher B. Eckman, M. Jensen — 1996
• Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor proteinDora Games, David S. Adams, Ree Alessandrini — 1995

Cited by

• Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.E. Losada, E. Niño Ricoi, J.M. Castro — 2005
• Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's DiseaseXUMancai, SHIZuoqing — 2010
• Modulation of Alzheimer’s Pathology in Transgenic Mouse ModelsCarmen Cecilia Duma — 2009
• The pathology of APP transgenic mice: a model of Alzheimer's disease or simply overexpression of APP?David Howlett, Jill Richardson — 2009
• Efecto del resveratrol en modelos murinos de envejecimiento y enfermedad de AlzheimerDavid Porquet Costa — 2014
• Postmortale Diagnosestellung bei Morbus AlzheimerD. R. Thal, H. Braak — 2005
• Transgenic mouse models of Alzheimer's disease: phenotype and applicationGuy A. Higgins, Heimut Jacobsen — 2003
• [Experimental models in Alzheimer's disease].Sagrario Manzano, J.A Castanon Gonzalez, Alberto Marcos — 2009
• Brain aging in dogs: parallels with human brain aging and Alzheimer's disease.Elizabeth Head — 2001
• Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy‐X04, a Systemically Administered Congo Red DerivativeWilliam E. Klunk, Brian J. Bacskai, Chester A. Mathis — 2002
• Evaluation and validation of new animal and behavioural models for the study of Alzheimer's diseaseIrena Goricanec — 2004
• Die Amyloidablagerung in einem Mausmodell der Alzheimer Demenz und die Modulation der β-Amyloid-Peptidentstehung durch membranverankerte InhibitorenHeinke Schieb — 2011
• Biological transgenic mouse models of Alzheimer's disease.Leslie Crews, Edward Rockenstein, Eliezer Masliah — 2008
• Presenilin‐1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ‐secretase modulators regardless of their potency and structureStefanie Hahn, Tanja Brüning, Julia Neß — 2011
• Neurotoxic Aβ peptides increase oxidative stress in vivo through NMDA‐receptor and nitric‐oxide‐synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitroJanice K. Parks, Trisha S. Smith, Patricia A. Trimmer — 2001
• Effects of Increased Iron Intake During the Neonatal Period on the Brain of Adult AβPP/PS1 Transgenic MiceLiana Lisboa Fernandez, Marga Carmona, Manuel Portero‐Otín — 2010
• NITRATION AND INACTIVATION OF MANGANESE SUPEROXIDE DISMUTASE PLAYS A CRITICAL ROLE IN METABOLIC SWITCHAnantharaman Muthuswamy — 2008
• Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s diseaseG. S. M. Sundaram, Dhruva D. Dhavale, Julie L. Prior — 2015
• Studies on the first described Alzheimer's disease amyloid β mutant, the Dutch variantEfrat Levy, Frances Prelli, Blas Frangione — 2006
• Identification of a BACE dimer and characterization of its biochemical and enzymatic propertiesGil G. Westmeyer — 2006

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