GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide
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Summary
The data indicate that changes in the subcellular trafficking of BACE1 or other GGA1-dependent proteins contribute to changes in APP processing and Aβ generation, and GGA proteins might be involved in the pathogenesis of AD.
- Type
- article
- Published
- 2006-12-06
- Cited by
- 87
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W17151287
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5000332
Keywords
Constitution, Competition (biology), Context (archaeology), Investment (military), Business
References
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- Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
- GGA Proteins Mediate the Recycling Pathway of Memapsin 2 (BACE)*
- Phosphorylation-induced Conformational Changes Regulate GGAs 1 and 3 Function at the Trans-Golgi Network*
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- Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
Cited by
- The cellular nucleic acid binding protein regulates the Alzheimer's disease beta-secretase protein BACE1
- GPR50, a potential factor involved in psychiatric disorders interacts with Alzheimer’s disease-related protein β- secretase (BACE1)
- Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain
- Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons
- Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease
- Proteolytic processing of the Alzheimer APP protein family during neuronal differentiation
- Investigating the Role of the Amyloid Precursor Protein in the Pathogenesis of Alzheimer's Disease
- β‐Site APP‐cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis
- β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
- The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)
- Neuronal protein trafficking associated with Alzheimer disease
- BACE1 structure and function in health and Alzheimer's disease.
- Drosophila GGA-model: an ultimate gateway to GGA analysis
- Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions
- Understanding BACE1: essential protease for amyloid-β production in Alzheimer’s disease
- SORLA/SORL1, a Neuronal Sorting Receptor Implicated in Alzheimer's Disease
- Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders.
- Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.
- Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.
- A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis
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