Toll-like receptors in the induction of the innate immune response
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Summary
A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
- Type
- review
- Published
- 2000-08-17
- Cited by
- 3,277
- References
- 58
- OpenAlex
- https://openalex.org/W1930598094
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4410405
Keywords
Innate immune system, Toll, Biology, Immune system, Receptor
References
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- A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
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- Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
- The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
- Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1
- The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
- Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania donovani lipophosphoglycan.
- Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila.
- Recognition of gram-negative bacteria and endotoxin by the innate immune system.
- MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.
- Lipid A diversity and the innate host response to bacterial infection.
- TLR6: A novel member of an expanding toll-like receptor family.
- TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
- Genetic organization of the lipopolysaccharide O-antigen biosynthetic locus of Leptospira borgpetersenii serovar Hardjobovis.
- Toll signaling pathways in the innate immune response.
- Unresponsiveness of MyD88-deficient mice to endotoxin.
- Signaling mechanisms in the antimicrobial host defense of Drosophila.
- TAK1 mediates an activation signal from toll‐like receptor(s) to nuclear factor‐κB in lipopolysaccharide‐stimulated macrophages
Cited by
- Differences in the expression of TLRs and inflammatory cytokines in pre-eclamptic compared with healthy pregnant women.
- Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway
- Cinderella goes to the ball
- The many roles of the class A macrophage scavenger receptor.
- Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes
- Does activation of the innate immune system contribute to the development of rheumatoid arthritis?
- Phagocytosis and the inflammatory response.
- Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent
- Interferon- : an overview of signals, mechanisms and functions
- Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense1
- NF-kappaB- and c-Jun-dependent regulation of human cytomegalovirus immediate-early gene enhancer/promoter in response to lipopolysaccharide and bacterial CpG-oligodeoxynucleotides in macrophage cell line RAW 264.7.
- Cross-Talk between CD14 and Complement Receptor 3 Promotes Phagocytosis of Mycobacteria: Regulation by Phosphatidylinositol 3-Kinase and Cytohesin-11
- Toll-like receptor mRNA expression patterns in human dendritic cells and monocytes.
- Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1.
- Converging actions of alcohol on liver and brain immune signaling.
- Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection.
- Outer Membrane Protein A of Escherichia coli O157:H7 Stimulates Dendritic Cell Activation
- Effect of carbon dioxide on neonatal mouse lung: a genomic approach.
- Toll-like Receptor 4 Region Glu24–Lys47 Is a Site for MD-2 Binding
- TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population.
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