Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.
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Summary
The cloning of two novel human genes, TIL3 and TIL4 (Toll/IL-1R-like-3, -4) that exhibit homology to both the leucine-rich repeat extracellular domains and the IL-1 R-like intracellular domains of human and Drosophila Toll are reported.
- Type
- article
- Published
- 1998-06-01
- Cited by
- 260
- References
- 51
- OpenAlex
- https://openalex.org/W166721574
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28329725
Keywords
Biology, Innate immune system, Gene, Genetics, Cell biology
References
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- cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
- Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila.
Cited by
- Immune-relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive hybridization.
- Cinderella goes to the ball
- MicroRNA‐181c negatively regulates the inflammatory response in oxygen‐glucose‐deprived microglia by targeting Toll‐like receptor 4
- Evolution of the TIR, tolls and TLRs: functional inferences from computational biology.
- Toward a Modern Synthesis of Immunity: Charles A. Janeway Jr. and the Immunologist’s Dirty Little Secret
- B‐cell activation by T‐cell‐independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms
- Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.
- Toxicological and Pharmacokinetic Properties of QPI-1007, a Chemically Modified Synthetic siRNA Targeting Caspase 2 mRNA, Following Intravitreal Injection
- Immunologie de la polypose nasosinusienne
- The role of toll-like receptor agonists in the immunotherapy of leishmaniosis. An update and proposal for a new form of anti-leishmanial therapy.
- Expression et fonctionnalité des Toll-Like récepteurs par les cellules de leucémie lymphoïde chronique B
- Toll-Like Receptor Family Members and Their Ligands
- TOLL-LIKE RECEPTOR 2 EXPRESSION, REGULATION AND SIGNALING
- Toll-like receptors.
- Etude de l'effet antitumoral de l'activation de la NO-synthase inductible dans un modèle de cancer du sein : analyse des mécanismes moléculaires
- The Effect of Hypoxia on the Production of Interleukin-10 (IL-10) In Human Mononuclear Cells
- Expression of Toll-like Receptor-2 on the Peripheral Blood Monocytes in Kawasaki Disease Patients
- Endotoxin and Cytokine Regulation of Toll-like Receptor (TLR) 2 and TLR4 Gene Expression in Murine Liver and Hepatocytes
- Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
- The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
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